Carol A Westbrook

6576421, Jun 10, 2003

Feb 11, 2000

09/502954

Carol A. Westbrook - Chicago IL

ARCH Development Corporation - Chicago IL

C12Q 168

435 6, 435 912, 536 231, 536243, 536 2431, 536 266

This invention relates generally to methods and compositions for direct detection of specific nucleic acid flanking sequences associated with structural chromosomal aberration breakpoints, by forming hybrids between the sequences and genetic probes, and detecting the probes. In particular aspects, the invention concerns detection of nucleic acid sequences in situ in chromosomes, and more specifically in cells, including interphase cells. Compositions of probes useful for detecting chromosomal translocations, in particular those associated with human leukemias, are also disclosed. An aspect of the invention is labelled probes that, when juxtaposed by formation of an aberration, are distinguishable and provide a pattern different from that of normal cells.

8415464, Apr 9, 2013

Jan 22, 2001

09/765291

Joe W. Gray - Livermore CA, US
Daniel Pinkel - Walnut Creek CA, US
Douglas Tkachuk - Livermore CA, US
Carol Westbrook - Goshen IN, US

The Regents of the University of California - Oakland CA
The University of Chicago - Chicago IL

C12N 15/32
C12N 5/071

536 2431, 435366

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyzes. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML) and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

20020152196, Oct 17, 2002

Jul 2, 2001

09/897798

Carol Westbrook - Chicago IL, US
Ronald Hoffman - Chicago IL, US

G06F007/00

707/001000

A unique database, a “transcriptosome” of a primate CD34+ cell, was compiled which is useful for the analysis and transplantation of bone marrow. Research and clinical applications arise from analysis of bone marrow, and related hemotopoietic tissues, prior to gene therapy or transplantation. Because the database contains many unknown and uncharacterized genes, an important use is the discovery of new genes that are relevant to hematopoiesis and stem cell growth. These genes may lead to further commercial products.

20030099987, May 29, 2003

Sep 6, 2002

10/236880

Carol Westbrook - Chicago IL, US

C12Q001/68
C07J017/00
C07H021/04

435/006000, 536/024300, 536/006100

This invention relates generally to methods and compositions for direct detection of specific nucleic acid flanking sequences associated with structural chromosomal aberration breakpoints, by forming hybrids between the sequences and genetic probes, and detecting the probes. In particular aspects, the invention concerns detection of nucleic acid sequences in situ in chromosomes, and more specifically in cells, including interphase cells. Compositions of probes useful for detecting chromosomal translocations, in particular those associated with human leukemias, are also disclosed. An aspect of the invention is labelled probes that, when juxtaposed by formation of an aberration, are distinguishable and provide a pattern different from that of normal cells.

20030105594, Jun 5, 2003

Jun 18, 2002

10/174513

Carol Westbrook - Chicago IL, US
Ronald Hoffman - Chicago IL, US

G06F019/00
G01N033/48
G01N033/50

702/019000, 702/020000

A unique database, a “transcriptosome” of a primate CD34+ cell, was compiled which is useful for the analysis and transplantation of bone marrow. Research and clinical applications arise from analysis of bone marrow, and related hemotopoietic tissues, prior to gene therapy or transplantation. Because the database contains many unknown and uncharacterized genes, an important use is the discovery of new genes that are relevant to hematopoiesis and stem cell growth. These genes may lead to further commercial products.

60251263, Feb 15, 2000

Oct 28, 1991

7/784222

Carol A. Westbrook - Chicago IL

Arch Development Corporation - Chicago IL

C12Q 168
C12P 1934
C07H 2102
C07H 2104

435 6

This invention relates generally to methods and compositions for direct detection of specific nucleic acid flanking sequences associated with structural chromosomal aberration breakpoints, by forming hybrids between the sequences and genetic probes, and detecting the probes. In particular aspects, the invention concerns detection of nucleic acid sequences in situ in chromosomes, and more specifically in cells, including interphase cells. Compositions of probes useful for detecting chromosomal translocations, in particular those associated with human leukemias, are also disclosed. An aspect of the invention is labelled probes that, when juxtaposed by formation of an aberration, are distinguishable and provide a pattern different from that of normal cells.