Inventors:
Robert Woodland - Worcester MA, US
Madelyn Schmidt - North Grafton MA, US
Brian Piekos - Boston MA, US
International Classification:
A01K067/027
C07H021/04
C12N005/06
US Classification:
800/004000, 435/354000, 536/023500
Abstract:
The invention features a transgenic animal, which expresses a Coxsackie-adenovirus receptor (CAR) in its cells. The invention provides a new animal model for effecting adenovirus-mediated gene delivery and for testing gene function in vivo, and also provides new opportunities to assess gene function in vitro using freshly isolated cells.