Inventors:
MARK DANIELS - COLUMBIA MO, US
BRET ULERY - COLUMBIA MO, US
DAVID PORCIANI - COLUMBIA MO, US
KWAKU TAWIAH - COLUMBIA MO, US
JOSIAH SMITH - COLUMBIA MO, US
LEAH CARDWELL - COLUMBIA MO, US
DONALD BURKE - COLUMBIA MO, US
ERIN NEWCOMER - WILDWOOD MO, US
International Classification:
C12N 15/115
A61K 38/10
A61K 38/16
A61P 35/00
A61K 9/107
Abstract:
The present invention is directed to a composition that includes an amphiphile, its use in a method of preventing and/or treating cancer, and its use in a method of producing a pharmaceutical composition. In certain embodiments, the amphiphile includes a hydrophilic peptide that binds to a Plenty of SH3 domain (POSH) and inhibits or disrupts a POSH scaffold network, a hydrophobic moiety, and an aptamer. The present invention is also directed to other POSH inhibitor complex biomolecules that do not contain a hydrophobic moiety.