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Brent M Dorr

from Phoenixville, PA
Age ~39
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Also known as:
Brent Matthew Dorr
Phone and address:
160 Shelbourne Ln, Phoenixville, PA 19460
Related to:
Kelli DorrBarry E Dorr
Connected to:
Abigail M Dorr, 40Annabelle B Dorr, 91Becky L Dorr, 64Brenda J Dorr, 64Celia Dorr, 57Chelsea Dorr, 30Gregg L Dorr, 56Jeffrey D Dorr, 64Jennifer R Dorr, 50Josh R Dorr, 47

Brent Dorr Phones & Addresses

  • 160 Shelbourne Ln, Phoenixville, PA 19460
  • King of Prussia, PA
  • Cambridge, MA
  • Somerville, MA
  • Cary, NC
  • 1 1St St, Cambridge, MA 02141

Work

Company: Gsk Sep 2018 Position: Team leader at glaxo smith kline phrmcuticals

Education

Degree: Doctorates, Doctor of Philosophy School / High School: Harvard University 2008 to 2014 Specialities: Biology, Chemistry

Skills

Protein Engineering • Directed Evolution • Biocatalysis • Enzyme Technology • Protein Design • Protein Labeling • Bioconjugation • Protein Conjugation • Surface Modification • Protein Folding • Cell Sorting

Industries

Biotechnology

Resumes

Resumes

Brent Dorr Photo 1

Team Leader At Glaxo Smith Kline Phrmcuticals

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Location:
Philadelphia, PA
Industry:
Biotechnology
Work:
Gsk
Team Leader at Glaxo Smith Kline Phrmcuticals
Harvard University Aug 2008 - Jun 2014
Graduate Student
Vanderbilt University Aug 2005 - May 2008
Research Intern, Meiler Lab
Max Planck Institute For Biophysical Chemistry Apr 2007 - Aug 2007
Summer Research Intern, Griesinger Lab
Education:
Harvard University 2008 - 2014
Doctorates, Doctor of Philosophy, Biology, Chemistry Vanderbilt University 2004 - 2008
Bachelors, Bachelor of Science, Mathematics, Biology, Chemistry
Skills:
Protein Engineering
Directed Evolution
Biocatalysis
Enzyme Technology
Protein Design
Protein Labeling
Bioconjugation
Protein Conjugation
Surface Modification
Protein Folding
Cell Sorting

Publications

Us Patents

Evolution Of Bond-Forming Enzymes

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US Patent:
20140057317, Feb 27, 2014
Filed:
Jun 20, 2013
Appl. No.:
13/922812
Inventors:
Irwin Chen - San Francisco CA, US
Brent M. Dorr - Somerville MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 9/52
C12P 21/02
US Classification:
435 681, 435220
Abstract:
Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example, evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are also provided herein, as are methods for using such evolved bond-forming enzymes. Kits comprising materials, reagents, and cells for carrying out the directed evolution methods described herein are also provided.

Carboxyesterase Polypeptides For Amide Coupling

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US Patent:
20210238565, Aug 5, 2021
Filed:
Apr 21, 2021
Appl. No.:
17/236928
Inventors:
- Redwood City CA, US
David Entwistle - San Carlos CA, US
Christopher Michael Micklitsch - Philadelphia PA, US
Vesna Mitchell - Santa Clara CA, US
Nikki Dellas - San Carlos CA, US
Xiyun Zhang - Fremont CA, US
Antoinette Sero - Foster City CA, US
Brent Dorr - King of Prussia PA, US
Douglas E. Fuerst - King of Prussia PA, US
International Classification:
C12N 9/18
Abstract:
The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Carboxyesterase Biocatalysts

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US Patent:
20210115417, Apr 22, 2021
Filed:
Dec 13, 2018
Appl. No.:
16/771279
Inventors:
- Brentford, Middlesex, GB
Brent M. DORR - Collegeville PA, US
Douglas E. FUERST - Collegeville PA, US
Katherina Joyce HONICKER - Collegeville PA, US
Lydia Sanchez JORDAN - Collegeville PA, US
James Patrick MORRISON - Collegeville PA, US
Nikolay V. PLOTNIKOV - Collegeville PA, US
Markus SCHOBER - Stevenage, GB
Rama VOLADRI - Redwood City CA, US
International Classification:
C12N 9/18
C12P 17/16
Abstract:
The present disclosure provides engineered carboxyesterase enzymes that have the ability to catalyze amide bond formation. Also provided are polynucleotides encoding the carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes to make commercially valuable amides. Also provided are amides that are made using the engineered carboxyesterase enzymes.

Carboxyesterase Polypeptides For Amide Coupling

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US Patent:
20190177707, Jun 13, 2019
Filed:
Dec 12, 2018
Appl. No.:
16/218003
Inventors:
- Redwood City CA, US
David Entwistle - San Carlos CA, US
Christopher Michael Micklitsch - Philadelphia PA, US
Vesna Mitchell - Santa Clara CA, US
Nikki Dellas - Mountain View CA, US
Xiyun Zhang - Fremont CA, US
Antoinette Sero - Foster City CA, US
Brent Dorr - King of Prussia PA, US
Douglas E. Fuerst - King of Prussia PA, US
International Classification:
C12N 9/18
Abstract:
The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.

Evolution Of Bond-Forming Enzymes

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US Patent:
20160244747, Aug 25, 2016
Filed:
Feb 22, 2016
Appl. No.:
15/049465
Inventors:
- Cambridge MA, US
Irwin Chen - San Francisco CA, US
Brent M. Dorr - Somerville MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 15/10
Abstract:
Strategies, systems, methods, reagents, and kits for the directed evolution of bond-forming enzymes are provided herein. Evolution products, for example, evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are also provided herein, as are methods for using such evolved bond-forming enzymes. Kits comprising materials, reagents, and cells for carrying out the directed evolution methods described herein are also provided.

Evolved Sortases And Use Thereof

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US Patent:
20160208233, Jul 21, 2016
Filed:
Sep 19, 2014
Appl. No.:
15/022985
Inventors:
- Cambridge MA, US
Brent M. Dorr - Somerville MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12N 9/52
C07K 14/47
C12P 21/00
Abstract:
Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind recognitions motifs comprising a LAXT or LPXS sequence. Also provided are methods (e.g., orthogonal transpeptidation and diagnostics methods) for using such sortases. Kits comprising materials, reagents, and cells for carrying out the methods described herein are also provided.

Sortase-Catalyzed Immobilization, Release, And Replacement Of Functional Molecules On Solid Surfaces

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US Patent:
20150284477, Oct 8, 2015
Filed:
Oct 30, 2013
Appl. No.:
14/439787
Inventors:
- Cambridge MA, US
- Boston MA, US
Carolyn Haller - Wellesley MA, US
David R. Liu - Lexington MA, US
Brent M. Dorr - Somerville MA, US
International Classification:
C07K 17/08
C12N 9/52
C08G 81/00
A61L 33/06
A61L 33/18
C12P 21/00
A61L 33/00
Abstract:
Compositions, reagents, kits, and methods for the reversible, covalent conjugation of functional molecules to engineered surfaces, e.g., surfaces of biomedical devices or used in analytical assays or industrial catalysis, are provided. The compositions, reagents, kits, and methods provided herein allow for the attachment, release, and replacement of functional molecules to and from engineered surfaces in vitro, in situ, and in vivo. Implantable vascular grafts, stents, catheters, and other medical devices with immobilized thrombomodulin-coated surfaces are provided. These molecules can be released from the device surface and replaced with fresh thrombomodulin via systemic administration of the respective reactants and without the need to remove the device.
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Brent M Dorr from Phoenixville, PA, age ~39 Get Report