Bonnie B Plikaytis

20110027349, Feb 3, 2011

Jan 12, 2009

12/812541

Suraj Sable - Atlanta GA, US
Bonnie B. Plikaytis - Atlanta GA, US
Thomas M. Shinnick - Atlanta GA, US

A61K 39/04
A61K 9/127
A61P 31/06

424450, 4242481, 977906, 977773

A vaccine is provided wherein a polypeptide or combination of peptides from is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as part of a prime-boost strategy with BCG vaccine to increase the immunoprotection in a subject such that prevention or elimination of disease is achieved. Finally, a pharmaceutical package is provided that encompasses a polypeptide vaccine for that when administered to a subject elicits immunoprotection.

56521065, Jul 29, 1997

Oct 25, 1995

8/548199

Bonnie B. Plikaytis - Tucker GA
Thomas M. Shinnick - Atlanta GA
Jack T. Crawford - Dunwoody GA

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

C12Q 168

435 6

The present invention provides methods of detecting or distinguishing the DNA of an individual strain of Mycobacterium tuberculosis utilizing the polymerase chain reaction (PCR). Reproducible, unique patterns can be produced allowing the identification of unknown M. tuberculosis DNA by performing this reaction and comparing the pattern produced to the known reproducible, unique patterns. The invention further provides a kit useful to detect or distinguish the DNA of an individual strain of M. tuberculosis in a sample, comprising specific primers for use in PCR. The present invention also provides a method of determining the presence of a multidrug-resistant M. tuberculosis by detecting the presence of a specific arrangement of genomic DNA. Such detection can be done using PCR or a ligase chain reaction (LCR). The present invention provides nucleic acid sequences useful in detecting multidrug-resistant M.

52485943, Sep 28, 1993

Jul 5, 1990

7/548011

Carol H. Aloisio - Norcross GA
George M. Carlone - Stone Mountain GA
Bonnie B. Plikaytis - Tucker GA
Jackie Sampson - College Park GA

The United States of America as represented by the Department of Health
and Human Services - Washington DC

G01N 33569
C07K 1528

435 732

A set of three unique monoclonal antibodies have been produced which recognize Legionella with particular specificity, without substantial cross-reactivity with non-Legionella bacteria. These monoclonal antibodies are useful as immunodiagnostic reagents for detecting Legionella.