Inventors:
- Bethesda MD, US
Bo Liang - Boyds MD, US
Shirin Munir - Bethesda MD, US
Anne Schaap Nutt - Austin TX, US
Ursula Buchholz - Silver Spring MD, US
Natalie Mackow - East Setauket NY, US
Peter Kwong - Washington DC, US
Barney Graham - Rockville MD, US
Jason McLellan - Norwich VT, US
Assignee:
The United States of America, as represented by the Secretary, Dept. of Health and Human Services - Bethesda MD
International Classification:
C07K 14/005
A61P 31/14
A61K 39/155
A61K 39/12
Abstract:
Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.