Inventors:
Patricia D. Murphy - Slingerland NY, US
Antonette C. Allen - Severn MD, US
Christopher P. Alvares - Potomac MD, US
Brenda S. Critz - Frederick MD, US
Sheri J. Olson - Arlington VA, US
Denise B. Schelter - Silver Spring MD, US
Bin Zeng - Rockville MD, US
Assignee:
Gene Logic Inc. - Gaithersburg MD
International Classification:
C12P 2106
C12N 500
C12N 1500
C12N 1563
C07H 2102
US Classification:
435 691, 4253201, 425325, 425455, 4252521, 425471, 536 231, 536 235
Abstract:
isolated coding sequences and to the protein sequences they code for. This invention is directed to three coding sequence of the BRCA1 gene. The three coding sequences, BRCA1, BRCA1, and BRCA1and their frequencies of occurrence are provided together with the protein sequences they code for. Another aspect of this invention is a method of determining the consensus sequence for any gene. Another aspect of the invention is a method of identifying an individual having an increased genetic susceptibility to breast or ovarian cancer because they have inherited a causative mutation in their BRCA1 gene. This invention is also related to a method of performing gene therapy with any of the isolated BRCA1 coding sequences.
