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Bhadra Shelat Phones & Addresses

  • Lake Forest, IL
  • San Jose, CA
  • Chicago, IL
  • North Chicago, IL
  • 1041 Breckenridge Ave, Lake Forest, IL 60045 (847) 409-1768

Work

Position: Executive, Administrative, and Managerial Occupations

Skills

Systems Analyst

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Resumes

Bhadra Shelat Photo 1

Bhadra Shelat

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Skills:
Systems Analyst

Publications

Us Patents

Synthesis Of Acyclic Nucleoside Derivatives

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US Patent:
7189849, Mar 13, 2007
Filed:
May 18, 2005
Appl. No.:
11/131646
Inventors:
M. Robert Leanna - Grayslake IL, US
Michael Rasmussen - Kenosha WI, US
Steven M. Hannick - Highland Park IL, US
Kirill A. Lukin - Mundelein IL, US
Zhenping Tian - Grayslake IL, US
Cynthia B. Curty - Gurnee IL, US
Bikshandarkoil A. Narayanan - Mundelein IL, US
John Bellettini - Waukegan IL, US
Bhadra Shelat - Lake Forest IL, US
Tiffany Spitz - Highland Park IL, US
Assignee:
Medivir AB - Huddinge
International Classification:
C07D 473/18
C07D 473/40
C07F 7/18
C07C 69/66
US Classification:
544276
Abstract:
Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

Modulators Of 5-Ht Receptors And Methods Of Use Thereof

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US Patent:
8518933, Aug 27, 2013
Filed:
Apr 22, 2010
Appl. No.:
12/765034
Inventors:
Ying Wang - Lake Villa IL, US
Jason T. Brewer - Zion IL, US
Stevan W. Djuric - Libertyville IL, US
Bhadra Shelat - Lake Forest IL, US
Frauke Pohlki - Mutterstadt, DE
Wilfried Braje - Mannhaim, DE
Ana-Lucia Relo - Gonnheim, DE
Assignee:
AbbVie Inc. - North Chicago IL
AbbVie Deutschland GmbH & Co. KG - Wiesbaden
International Classification:
C07D 515/00
A61K 31/553
A61P 25/00
US Classification:
5142111, 540548
Abstract:
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2 -a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7 -octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2 -a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I).

Synthesis Of Acyclic Nucleoside Derivatives

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US Patent:
20040248910, Dec 9, 2004
Filed:
Jun 17, 2004
Appl. No.:
10/871751
Inventors:
M. Leanna - Grayslake IL, US
Steven Hannick - Highland Park IL, US
Michael Rasmussen - Kenosha WI, US
Lakshmi Bhagavatula - Vernon Hills IL, US
Pulla Singam - Des Plaines IL, US
Bradley Gates - Mount Prospect IL, US
Lawrence Kolaczkowski - Gurnee IL, US
Ramesh Patel - Chicago IL, US
Greg Wayne - Vernon Hills IL, US
Greg Lannoye - Wildwood IL, US
Weijiang Zhang - Grayslake IL, US
Zhenping Tian - Grayslake IL, US
Kirill Lukin - Mundelein IL, US
Bikshandarkoil Narayanan - Mundelein IL, US
David Riley - Kenosha WI, US
Howard Morton - Gurnee IL, US
Cynthia Curty - Gurnee IL, US
Daniel Plata - Wadsworth IL, US
John Bellettini - Waukegan IL, US
Bhadra Shelat - Lake Forest IL, US
Tiffany Spitz - Highland Park IL, US
Assignee:
Medivir AB - Huddinge
International Classification:
A61K031/522
C07D487/12
US Classification:
514/263380, 544/276000
Abstract:
Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of Rand Ris an amino acid acyl group and the other of Rand Ris a —C(O)C-Csaturated or monounsaturated, optionally substituted alkyl and Ris OH or H; or a pharmaceutically acceptable salt thereof.

Modulators Of 5-Ht Receptors And Methods Of Use Thereof

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US Patent:
20130310368, Nov 21, 2013
Filed:
Jul 22, 2013
Appl. No.:
13/947995
Inventors:
- Wiesbaden, DE
Stevan W. Djuric - Libertyville IL, US
Bhadra Shelat - Lake Forest IL, US
Frauke Pohlki - Mutterstadt, DE
Wilfried Braje - Mannheim, DE
Ana-Lucia Relo - Gonnheim, DE
International Classification:
C07D 487/04
US Classification:
51421402, 540497
Abstract:
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I)wherein R, R, R, R, R, R, X, X, X, X, Y, Y, and Yare as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Process For The Preparation Of N-4-[(Substituted Phenyl)Alkylheterocyclic]- N

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US Patent:
55809898, Dec 3, 1996
Filed:
Jun 7, 1995
Appl. No.:
8/472448
Inventors:
James D. Ratajczyk - Waukegan IL
Juliette K. Busse - Winthrop Harbor IL
Sanjay R. Chemburkar - Gurnee IL
Daniel A. Dickman - Grayslake IL
Yi-Yin Ku - Buffalo Grove IL
Hemantkumar H. Patel - Waukegan IL
Ramesh R. Patel - Chicago IL
David P. Sawick - Wildwood IL
John N. Starr - Grayslake IL
Bhadra Shelat - Lake Forest IL
Harry O. Spiwek - Kenosha WI
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C07D33322
C07D30736
US Classification:
549 77
Abstract:
A process for preparing a compound of the structure I ##STR1## where A is oxygen and sulfur and R. sup. 1 is selected from the group consisting of hydrogen, halogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, and trifluoromethyl, and R. sup. 2 is alkyl of one to four carbon atoms, comprising coupling a compound of formula II: ##STR2## where X is bromine or iodine, with an N-hydroxyurea compound of formula III: ##STR3## in the presence of a palladium catalyst followed by reaction of the product thus formed with an alkali metal isocyante. The compounds of formula I are inhibitors of the enzyme 5-lipoxygenase and are thus useful as therapeutic agents for the treatment of allergic and inflammatory disease conditions.

Synthesis Of Acyclic Nucleoside Derivatives

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US Patent:
61843768, Feb 6, 2001
Filed:
Aug 6, 1998
Appl. No.:
9/130214
Inventors:
M. Robert Leanna - Grayslake IL
Steven M. Hannick - Highland Park IL
Michael Rasmussen - Kenosha WI
Lakshmi Bhagavatula - Vernon Hills IL
Pulla Reddy Singam - Des Plaines IL
Bradley D. Gates - Mount Prospect IL
Lawrence Kolaczkowski - Gurnee IL
Ramesh R. Patel - Chicago IL
Greg Wayne - Vernon Hills IL
Greg Lannoye - Wildwood IL
Weijiang Zhang - Grayslake IL
Zhenping Tian - Grayslake IL
Kirill A. Lukin - Mundelein IL
Bikshandarkoil A. Narayanan - Mundelein IL
David A. Riley - Kenosha WI
Howard Morton - Gurnee IL
Cynthia B. Curty - Gurnee IL
Daniel Plata - Wadsworth IL
John Bellettini - Waukegan IL
Bhadra Shelat - Lake Forest IL
Tiffany Spitz - Highland Park IL
Assignee:
Mediver AB - Huddinge
International Classification:
C07D47318
C07D47340
C07D31730
C07F 718
C12P 1718
US Classification:
544229
Abstract:
Methods and novel intermediates of the formula: ##STR1## wherein R. sub. 6 and R. sub. 7 are lower alkyl or benzyl or R. sub. 6 and R. sub. 7 taken together are --CH. sub. 2 CH. sub. 2 --, --CH. sub. 2 CH. sub. 2 CH. sub. 2 -- or --CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 CH. sub. 2 --, R. sub. 8 is C. sub. 1 -C. sub. 21 alkyl or a C. sub. 2 -C. sub. 21 monounsaturated alkenyl, which may optionally be substituted with substitution substituents independently selected from the group consisting of hydroxy, C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkoxy, C. sub. 1 -C. sub. 6 alkoxy C. sub. 1 -C. sub. 6 alkyl, C. sub. 1 -C. sub. 6 alkanoyl, amino, halo, cyano, azido, oxo, mercapto and nitro, and R. sub. 9 is an alcohol protecting group. The intermediates are useful for the preparation of acyclic nucleoside derivatives of the formula: ##STR2## where one of R. sub. 1 and R. sub.

Modulators Of 5-Ht Receptors And Methods Of Use Thereof

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US Patent:
20180127423, May 10, 2018
Filed:
Jul 7, 2017
Appl. No.:
15/643924
Inventors:
- Wiesbaden, DE
- North Chicago IL, US
Stevan W. Djuric - Libertyville IL, US
Bhadra Shelat - Lake Forest IL, US
Frauke Pohlki - Mutterstadt, DE
Wilfried Braje - Mannheim, DE
Ana-Lucia Relo - Gonnheim, DE
International Classification:
C07D 487/04
C07D 487/14
C07D 498/04
C07D 491/04
C07D 471/14
C07D 471/04
Abstract:
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I)wherein R, R, R, R, R, R, X, X, X, X, Y, Y, and Yare as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Modulators Of 5-Ht Receptors And Methods Of Use Thereof

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US Patent:
20150175611, Jun 25, 2015
Filed:
Sep 30, 2014
Appl. No.:
14/503198
Inventors:
- Wiesbaden, DE
- North Chicago IL, US
Stevan W. Djuric - Libertyville IL, US
Bhadra Shelat - Lake Forest IL, US
Frauke Pohlki - Mutterstadt, DE
Wilfried Braje - Mannheim, DE
Ana-Lucia Relo - Gonnheim, DE
International Classification:
C07D 487/04
C07D 487/14
C07D 498/04
Abstract:
The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I)wherein R, R, R, R, R, R, X, X, X, X, Y, Y, and Yare as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
Bhadra H Shelat from Lake Forest, IL, age ~77 Get Report