Inventors:
Robert Graziano - Frenchtown NJ, US
Josephine M. Cardarelli - San Carlos CA, US
Thomas D. Kempe - Sunnyvale CA, US
Beth Cutter - Livermore CA, US
Mohan Srinivasan - San Jose CA, US
International Classification:
A61K 39/395
C07K 16/18
A61P 43/00
US Classification:
4241721, 5303879, 5303873, 5303877
Abstract:
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-5 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-5, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma.
