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Bernhard H Geierstanger

from Solana Beach, CA
Age ~61
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Also known as:
Vernhard Geierstanger, Bernhard R
Phone and address:
482 Santa Cecelia, Solana Beach, CA 92075
(858) 755-9636
Related to:
Maryanne Sather Peterson, 66Helen JohnsonNathan JohnsonBryan Peterson, 38Judith Peterson, 85James Peterson, 78
Connected to:
Jennifer L Geigan, 40Anna K Geigel, 61Candido G Geigel, 79Hiram L Geigel, 44Marcos F Geigel, 44Michelle C Geigel, 53Sandra Geigel, 70Albert G Geigele, 94Allie Geiger, 31Amarilis Geiger, 66

Bernhard Geierstanger Phones & Addresses

  • 482 Santa Cecelia, Solana Beach, CA 92075 (858) 755-9636
  • 155 15Th St, Del Mar, CA 92014
  • 5994 Cozzens St, San Diego, CA 92122
  • Sonoma, CA
  • Berkeley, CA
  • Menlo Park, CA
  • Palo Alto, CA

Work

Company: Gnf Sep 2018 Position: Executive director, biotherapeutics

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of California, Berkeley 1990 to 1994 Specialities: Biophysics, Philosophy

Skills

Biochemistry • Protein Chemistry • Assay Development • Biotechnology • Drug Development • Protein Engineering • Nmr • Organic Chemistry • Life Sciences • Leadership • Science • Cell Biology • Cell • Drug Discovery • Molecular Biology • Enzymes • Pharmaceutical Industry • Nuclear Magnetic Resonance • Cell Culture

Industries

Biotechnology

Resumes

Resumes

Bernhard Geierstanger Photo 1

South San Francisco, California

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Location:
South San Francisco, CA
Industry:
Biotechnology
Work:
Gnf
Executive Director, Biotherapeutics
Gnf Jan 2018 - Sep 2018
Ad Interim, Co-Leader, Department of Biotherapeutics and Biotechnology
Gnf Jun 2016 - Sep 2018
Director, Protein Design and Function
Gnf Mar 2013 - Jun 2016
Director, Protein Engineering
Gnf Jun 2009 - Mar 2013
Associate Director, Protein Engineering
Education:
University of California, Berkeley 1990 - 1994
Doctorates, Doctor of Philosophy, Biophysics, Philosophy Oregon State University 1988 - 1990
Master of Science, Masters, Biochemistry, Biophysics
Skills:
Biochemistry
Protein Chemistry
Assay Development
Biotechnology
Drug Development
Protein Engineering
Nmr
Organic Chemistry
Life Sciences
Leadership
Science
Cell Biology
Cell
Drug Discovery
Molecular Biology
Enzymes
Pharmaceutical Industry
Nuclear Magnetic Resonance
Cell Culture

Publications

Us Patents

Site-Specific Labeling Of Proteins For Nmr Studies

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US Patent:
20060110784, May 25, 2006
Filed:
Sep 21, 2005
Appl. No.:
11/233466
Inventors:
Alexander Deiters - Raleigh NC, US
Bernhard Geierstanger - Del Mar CA, US
Peter Schultz - La Jolla CA, US
Assignee:
The Scripps Research Institute - La Jolla CA
IRM, LLC - Hamilton
International Classification:
C12Q 1/37
G01N 33/00
C12N 15/74
C12N 1/21
C12N 5/06
C12N 1/18
US Classification:
435023000, 435483000, 435488000, 435252330, 435325000, 435254200, 436086000
Abstract:
Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled proteins, are also provided.

Site-Specific Labeling Of Proteins For Nmr Studies

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US Patent:
20080171317, Jul 17, 2008
Filed:
Sep 21, 2005
Appl. No.:
11/662814
Inventors:
Alexander Deiters - Raleigh NC, US
Bernhard H. Geierstanger - Del Mar CA, US
Peter G. Schultz - La Jolla CA, US
Assignee:
THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA
IRM, LLC - Hamilton
International Classification:
C12Q 1/68
G01N 24/00
US Classification:
435 6, 436173
Abstract:
Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled proteins, are also provided.

Site-Specific Labeling Of Proteins For Nmr Studies

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US Patent:
20090081690, Mar 26, 2009
Filed:
Nov 17, 2008
Appl. No.:
12/313321
Inventors:
Alexander Deiters - Raleigh NC, US
Bernhard H. Geierstanger - Del Mar CA, US
Peter G. Schultz - La Jolla CA, US
International Classification:
G01N 33/68
G06F 19/00
US Classification:
435 6, 702 19
Abstract:
Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled proteins, are also provided.

Biosynthetically Generated Pyrroline-Carboxy-Lysine And Site Specific Protein Modifications Via Chemical Derivatization Of Pyrroline-Carboxy-Lysine And Pyrrolysine Residues

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US Patent:
20110262963, Oct 27, 2011
Filed:
Oct 23, 2009
Appl. No.:
13/125547
Inventors:
Bernhard Geierstanger - Solana Beach CA, US
Weijia Ou - San Diego CA, US
Susan E. Cellitti - San Diego CA, US
Tetsuo Uno - San Diego CA, US
Tiffany Crossgrove - San Diego CA, US
Jan Grunewald - San Diego CA, US
Xueshi Hao - San Diego CA, US
International Classification:
C12P 21/02
C07D 207/22
C07K 16/00
C12P 21/08
C07K 14/485
C12N 11/18
C12N 9/90
C07K 14/50
C07K 14/525
C07K 14/435
C07K 14/505
US Classification:
435 681, 530350, 548537, 5303871, 530397, 435175, 435233, 530399, 530351
Abstract:
Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein.

Methods Of Treating Fgf21-Associated Disorders

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US Patent:
20120129766, May 24, 2012
Filed:
Nov 15, 2011
Appl. No.:
13/296343
Inventors:
Brian R. BOETTCHER - Winchester MA, US
Shari L. CAPLAN - Lunenburg MA, US
Douglas S. DANIELS - Arlington MA, US
Bernhard H. GEIERSTANGER - Solana Beach CA, US
Norio HAMAMATSU - Belmont MA, US
Stuart LICHT - Cambridge MA, US
Andreas LOEW - Somerville MA, US
Stephen Craig WELDON - Leominster MA, US
Assignee:
IRM LLC - HAMILTON
NOVARTIS AG - BASEL
International Classification:
A61K 38/18
C08G 65/334
C07K 19/00
A61P 1/18
A61P 3/04
A61P 3/00
A61P 1/16
A61P 3/06
C07K 14/50
A61P 3/10
US Classification:
514 48, 530399, 530397, 525 541, 5303873, 530363, 514 91, 514 69, 514 74, 514 73, 514 67
Abstract:
The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods for treating FGF21-associated disorders, including metabolic conditions.

Site-Specific Labeling Methods And Molecules Produced Thereby

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US Patent:
20140065171, Mar 6, 2014
Filed:
May 31, 2013
Appl. No.:
13/906584
Inventors:
Bernhard Hubert GEIERSTANGER - Solana Beach CA, US
Jan GRUNEWALD - San Diego CA, US
Badry BURSULAYA - Escondito CA, US
International Classification:
C07K 16/30
US Classification:
4241791, 5303873, 5303915, 5303919, 536 2353, 43525423, 4352546, 435328, 435 696
Abstract:
The present invention provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates.

Apparatus And Methods To Process Substrate Surface Features

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US Patent:
20040141887, Jul 22, 2004
Filed:
Nov 7, 2003
Appl. No.:
10/704204
Inventors:
James Mainquist - San Diego CA, US
Bernhard Geierstanger - Del Mar CA, US
David Tully - San Diego CA, US
Assignee:
IRM, LLC - Hamilton HM LX
International Classification:
B01L003/00
US Classification:
422/102000, 422/101000
Abstract:
The present invention provides apparatus for fluidly separating substrate surface features. The apparatus include arrays of apertures that correspond to at least a portion of an array of wells disposed in a micro-well plate and/or are structured to fluidly separate multiple surface features disposed on multiple substrates from one another. Related systems, kits, and methods are additionally provided.

Antibody Conjugates Comprising Toll-Like Receptor Agonist

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US Patent:
20210346387, Nov 11, 2021
Filed:
Feb 22, 2021
Appl. No.:
17/181896
Inventors:
- Basel, CH
Bernhard Hubert GEIERSTANGER - Solana Beach CA, US
Timothy Z. HOFFMAN - San Diego CA, US
Shailaja KASIBHATLA - San Diego CA, US
Tetsuo UNO - San Diego CA, US
Xing WANG - San Diego CA, US
Tom Yao-Hsiang WU - San Diego CA, US
International Classification:
A61K 31/52
A61K 47/68
C07D 487/04
C07H 15/26
C07K 16/28
C07K 16/32
Abstract:
Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.
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Bernhard H Geierstanger from Solana Beach, CA, age ~61 Get Report