Bernadene A Magnuson

7130834, Oct 31, 2006

Nov 27, 2001

09/995257

Kim A. Anderson - Troy ID, US
Brian Smith - Troy ID, US
Bernadene Magnuson - Moscow ID, US

Idaho Potato Commission - Eagle ID

G06N 3/02

706 15, 706 20

The detection method includes generating a plurality of neural network models. Each model has as a training set a data set from a plurality of samples of a commodity of known origins. Each sample has been analyzed for a plurality of elemental concentrations. Each neural network model is presented for classification a test data set from a plurality of samples of a commodity of unknown origins. As with the training set, the samples have been analyzed for the same plurality of elemental concentrations. Next a bootstrap aggregating strategy is employed to combine the results of the classifications for each sample in the test data set made by each neural network model. Finally, a determination is made from the bootstrap aggregating strategy as to a final classification of each sample in the test data set. This final classification is indicative of the geographical origin of the commodity. The system includes software for generating the neural network models and a software routine for performing the bootstrap aggregating strategy.

8034388, Oct 11, 2011

Mar 23, 2006

11/388163

Bernadene Ann Magnuson - Columbia MD, US
M. Monica Giusti - Dublin OH, US
Minnie Malik - Olney OH, US
Cuiwei Zhao - Ellicott City MD, US

The University of Maryland - Riverdale MD

A61K 36/00
A61K 36/73
A61K 36/45

424732, 424725

The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.

20050013880, Jan 20, 2005

Mar 8, 2004

10/795967

Bernadene Magnuson - Columbia MD, US
M. Giusti - Dublin OH, US
Minnie Malik - Olney MD, US
Cuiwei Zhao - Ellicott City MD, US

A61K035/78
A61K031/7048
A61K031/353

424732000, 424766000, 514027000, 514456000

The present invention provides compositions and methods for inhibiting the growth and cell cycle progression in carcinoma cells comprising the step of contacting the cells with an anthocyanin rich extract (ARE) in an amount effective to inhibit the growth and cell cycle progression of the carcinoma cells without effecting the growth and cell cycle progression on normal cells. The invention further provides therapeutic compositions and methods of inhibiting the growth and cell cycle progression of carcinoma cells in a patient comprising administering to a patient a therapeutically effective amount of an anthocyanin-rich extract with the proviso that the anthocyanin rich extract does not effect the growth and cell cycle progression of normal cells in the patient. In preferred embodiments, the anthocyanin-rich extract useful in the compositions and methods of the invention are derived from chokeberry, bilberry, grape or combinations thereof. In preferred embodiments the carcinoma cells are colon carcinoma cells.

20060024392, Feb 2, 2006

Apr 14, 2005

11/106240

Bernadene Magnuson - Columbia MD, US
Tao Yu - Laurel MD, US

The University of Maryland - College Park MD

A61K 36/45

424732000

This invention relates to food components such as phytochemicals including anthocyanins that can enhance the effectiveness of a chemotherapeutic agent in treating a cell proliferative disorder and/or reduce chemotherapy-induced side effects during treatment of a cell proliferative disorder.

63245310, Nov 27, 2001

Dec 11, 1998

9/210358

Kim A. Anderson - Troy ID
Brian Smith - Troy ID
Bernadene Magnuson - Moscow ID

Florida Department of Citrus - Lakeland FL
Idaho Potato Commission - Boise ID

G06N 302

706 15

The detection method includes generating a plurality of neural network models. Each model has as a training set a data set from a plurality of samples of a commodity of known origins. Each sample has been analyzed for a plurality of elemental concentrations. Each neural network model is presented for classification a test data set from a plurality of samples of a commodity of unknown origins. As with the training set, the samples have been analyzed for the same plurality of elemental concentrations. Next a bootstrap aggregating strategy is employed to combine the results of the classifications for each sample in the test data set made by each neural network model. Finally, a determination is made from the bootstrap aggregating strategy as to a final classification of each sample in the test data set. This final classification is indicative of the geographical origin of the commodity. The system includes software for generating the neural network models and a software routine for performing the bootstrap aggregating strategy.