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Benson Sibanda Phones & Addresses

  • 3964 Waring Rd, Oceanside, CA 92056 (760) 630-5585
  • Riverside, CA
  • Vista, CA
  • 3964 Waring Rd APT 5, Oceanside, CA 92056

Publications

Us Patents

Liver Reserve Cells

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US Patent:
55590225, Sep 24, 1996
Filed:
Jan 26, 1995
Appl. No.:
8/378762
Inventors:
Brian A. Naughton - El Cajon CA
Benson Sibanda - Oceanside CA
Assignee:
Advanced Tissue Sciences, Inc. - La Jolla CA
International Classification:
C12N 506
C12N 508
US Classification:
4352402
Abstract:
The present invention relates to liver reserve or progenitor cells. In particular, it relates to the isolation, characterization, culturing, and uses of liver reserve cells. Liver reserve cells isolated by density gradient centrifugation can be distinguished from other liver parenchymal cells by their morphology, staining characteristics, high proliferative activity and ability to differentiate in vitro. In long-term cultures described herein, these cells expand in numbers and differentiate into morphologically mature liver parenchymal cells, capable of mediating liver-specific functions. Therefore, isolated liver reserve cells may have a wide range of applications, including, but not limited to, their uses as vehicles of exogenous genes in gene therapy, and/or to replace and reconstitute a destroyed, infected, or genetically deficient mammalian liver by transplantation.

Method For Culturing Three-Dimensional Tissue In Diffusion Gradient Bioreactor And Use Thereof

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US Patent:
62181823, Apr 17, 2001
Filed:
Dec 21, 1999
Appl. No.:
9/470317
Inventors:
Brian A. Naughton - El Cajon CA
Craig R. Halberstadt - La Jolla CA
Benson Sibanda - Oceanside CA
Assignee:
Advanced Tissue Sciences - La Jolla CA
International Classification:
A01N 102
C12N 500
C12M 100
C12M 300
C12M 306
US Classification:
435395
Abstract:
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media; allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.

Diffusion Gradient Bioreactor And Extracorporeal Liver Device Using A Three-Dimensional Liver Tissue

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US Patent:
58277293, Oct 27, 1998
Filed:
Apr 23, 1996
Appl. No.:
8/636591
Inventors:
Brian A. Naughton - El Cajon CA
Craig R. Halberstadt - La Jolla CA
Benson Sibanda - Oceanside CA
Assignee:
Advanced Tissue Sciences - La Jolla CA
International Classification:
B01D 6300
C12N 500
US Classification:
4352972
Abstract:
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.

Diffusion Gradient Bioreactor And Extracorporeal Liver Device

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US Patent:
60080493, Dec 28, 1999
Filed:
Aug 19, 1998
Appl. No.:
9/136503
Inventors:
Brian A. Naughton - El Cajon CA
Craig R. Halberstadt - La Jolla CA
Benson Sibanda - Oceanside CA
Assignee:
Advanced Tissue Sciences, Inc. - La Jolla CA
International Classification:
A01N 102
C12N 500
C12M 100
C12M 300
C12M 306
US Classification:
435395
Abstract:
A tissue engineering bioreactor is disclosed for growing three-dimensional tissue. Cells are seeded onto a mesh and provided with two media flows, each contacting a different side of the cells. The media flows contain different concentrations of nutrients, allowing nutrients to be delivered to the cells by diffusion gradient. The bioreactor can be used to grow liver tissue, and designed as an extracorporeal liver assist device in which blood or plasma is exposed to the three-dimensional liver tissue. The blood or plasma from a patient directed to flow against the liver tissue. The liver tissue is further exposed on its opposite side to media providing nutrients and gases. The device provides porous boundaries between the blood or plasma, tissue, and media, allowing nutrient and protein delivery by diffusion gradient to dialyze a patient's blood.
Benson L Sibanda from Oceanside, CADeceased Get Report