US Patent:
20120178691, Jul 12, 2012
Inventors:
Volker Schellenberger - Palo Alto CA, US
Pei-Yun Chang - Menlo Park CA, US
Fatbardha Varfaj - Mountain View CA, US
Joshua Silverman - Sunnyvale CA, US
Chia-Wei Wang - Milpitas CA, US
Benjamin Spink - San Carlos CA, US
Nathan Geething - San Juan PR, US
Assignee:
Amunix Operating Inc. - Mountain View CA
International Classification:
A61K 38/37
C12N 15/62
C12N 15/63
A61P 7/04
C12N 1/19
C12N 1/15
C12N 1/21
C07K 19/00
C12N 5/10
US Classification:
514 141, 530383, 536 234, 4353201, 435325, 435365, 435352, 435358, 435369, 435353, 435354, 435366, 4352542, 43525421, 43525423, 43525411, 4352543, 4352544, 4352547, 4352546, 4352523, 43525233, 43525231, 43525234, 43525235
Abstract:
The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.