US Patent:
20080233181, Sep 25, 2008
Inventors:
Jon O. Nagy - Bozeman MT, US
Benfang Lei - Bozeman MT, US
Zengshe Kevin Liu - Morton IL, US
Robert F. Bargatze - Bozeman MT, US
John W. Jutila - Bozeman MT, US
Jim E. Cutler - New Orleans LA, US
Pati M. Glee - Bozeman MT, US
International Classification:
A61K 9/127
A61K 39/00
A61P 37/00
US Classification:
424450, 4241841, 4242441, 4242461, 4242771, 4242041, 4242651, 4242741
Abstract:
The present invention relates to nanoparticle vaccine adjuvants comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also display a targeting molecule on its surface in order to direct it to a specific site or cell type to optimize a desired immune response. The present invention also relates to encapsulating an antigen or combinations of different antigens within such nanoparticles, with or without a targeting molecule displayed on its surface. The antigens used in this invention are effective to produce an immune response against a variety of pathological conditions.
