Barron W Tenney

7737060, Jun 15, 2010

Mar 31, 2006

11/395964

Frederick H. Strickler - Natick MA, US
Barron Tenney - Haverhill MA, US

Boston Scientific Scimed, Inc. - Maple Grove MN

B32B 5/02
B32B 27/12
B32B 15/14
A61F 2/01
A61F 2/02
A61F 2/82
A61F 13/00

442361, 442123, 442199, 442200, 442201, 442202, 442228, 442229, 442238, 442362, 442363, 442364, 442365, 442376, 442377, 602 44, 602 45, 6048911, 604 9301, 606228, 606230, 606908, 606910

According to an aspect of the present invention, medical devices are provided that contain at least one multi-component polymeric fiber. The multi-component polymeric fiber further contains at least two components of differing composition.

8221783, Jul 17, 2012

Sep 10, 2008

12/207839

Michael N. Helmus - Worcester MA, US
Yixin Xu - Newton MA, US
Barron W. Tenney - Haverhill MA, US
Paul L. Valint - Pittsford NY, US
Shrirang V. Ranade - Arlington MA, US

Boston Scientific Scimed, Inc. - Maple Grove MN

C08B 37/08
C08L 71/02
A61K 47/36
A61K 47/42
A61K 9/70
A61K 9/00
A61K 31/337
A61K 31/436
A61K 47/38
A61F 2/02
C07K 14/78
C08F 210/00
C08G 63/06
C08G 67/00
C08G 73/00
C08G 73/10

424434, 424422, 526348, 526258, 528367, 536 56, 536 30, 536 58, 536 3, 536 20, 525408, 530354, 5147723, 5147724, 5147726, 514291, 514279, 514449, 514777, 514779, 514781, 514773, 514774, 623 1111, 623 116, 623 146, 623 142, 623 136

Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue.

8574615, Nov 5, 2013

May 25, 2010

12/787209

Barron Tenney - Haverhill MA, US
Yixin Xu - Newton MA, US
Michael N. Helmus - Worcester MA, US

Boston Scientific Scimed, Inc. - Maple Grove MN

A61F 2/02

424423

According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.

20050208107, Sep 22, 2005

Mar 16, 2004

10/801228

Michael Helmus - Worcester MA, US
Barron Tenney - Haverhill MA, US

A61F002/06
A61K009/70

424443000, 442123000, 623001110

According to an aspect of the present invention, a fiber comprising a styrene-isobutylene copolymer is formed by via a dry spinning process. Specific examples of copolymers for the practice of the present invention include copolymers comprising a polyisobutylene block and a polystyrene block, for instance, a polystyrene-polyisobutylene-polystyrene triblock copolymer. Other aspects of the present invention relate to medical articles which comprise the above dry spun fibers. Specific examples include medical articles comprising a woven region formed from the dry spun fibers, and medical articles comprising a non-woven region formed from the dry spun fibers.

20070110786, May 17, 2007

Nov 15, 2005

11/274538

Barron Tenney - Haverhill MA, US
Michael Helmus - Worcester MA, US

A61K 48/00
A61F 2/02

424423000, 514044000

According to an aspect of the present invention, medical articles are provided which comprise the following (a) a polymeric region having a first charge, and (b) a charged therapeutic agent having a second charge that is opposite in sign to that of the first charge. In certain beneficial embodiments, the medical articles are high surface area articles, for example, articles formed using small diameter (e.g., 10 microns or less) fibers.

20070224235, Sep 27, 2007

Mar 24, 2006

11/388604

Barron Tenney - Haverhill MA, US
Yixin Xu - Newton MA, US
Michael Helmus - Worcester MA, US

A61F 2/06

424423000, 623001110

According to an aspect of the present invention, implantable or insertable medical devices are provided which contain (a) one or more depressions that contain at least one therapeutic agent, and (b) a nanoporous coating, disposed over the therapeutic-agent-containing depressions, which regulate transport of species between the therapeutic-agent-containing depressions and the exterior of the device. The implantable or insertable devices are configured to preform a role beyond mere drug delivery, for example, providing mechanical and/or electrical functions within the body, among other functions. An advantage of the present invention is that medical devices may be provided, which release therapeutic agents in quantities far exceeding the void volume within the nanoporous coating, while at the same time providing functionality that extends beyond drug delivery. Such release may further approach or achieve a zero order kinetic drug release profile.

20080086113, Apr 10, 2008

Oct 10, 2006

11/545439

Barron Tenney - Haverhill MA, US
Michael N. Helmus - Worcester MA, US
Yixin Xu - Newton MA, US

A61K 9/22

6048921

According to an aspect of the invention, implantable or insertable medical devices are provided which contain the following: (a) one or more porous regions comprising pores and (b) one or more therapeutic agents which are (i) contained within the porous region, (ii) disposed beneath the porous region, or (iii) both. Moreover, the porous regions are capable of undergoing a change in configuration, such that the pores undergo a change in configuration, upon subjecting the porous regions to activating stimuli.

20080208325, Aug 28, 2008

Feb 25, 2008

12/072141

Michael N. Helmus - Worcester MA, US
Barron Tenney - Haverhill MA, US
Yixin Xu - Newton MA, US
Kevin M. Alves - New Bedford MA, US
Frederick H. Strickler - Natick MA, US
Kathleen M. Miller - Shrewsbury MA, US
Mark Boden - Harrisville RI, US

Boston Scientific Scimed, Inc. - Maple Grove MN

A61F 2/06

623 144, 623 113, 623 115, 623 139

According to an aspect of the present invention, long term medical articles are provided which include the following: (a) first and second body contacting (e.g., tissue and/or body-fluid contacting) porous polymeric layers; (b) a polymeric barrier layer disposed between the first and second porous polymer layers; and (c) a reinforcement element. According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: (a) a reinforcement element; (b) a blood contacting porous polymeric layer having a surface energy ranging between 20 and 30 dynes/cm disposed over an inner surface of the reinforcement element; and (c) an additional porous polymeric layer formed over an outer surface of the reinforcement element.