Inventors:
Toshiyuki Mori - Osaka, JP
Daniel W. McVicar - Charles Town WV, US
Barbara Giomarelli - Frederick MD, US
A. V. Washington - Bayamon PR, US
Assignee:
Government of the US, as represented by the Secretary, Dept. of Health and Human Services - Rockville MD
International Classification:
A61K 39/395
A61P 29/00
A61P 31/04
A61P 35/00
A61P 9/00
C07K 16/00
C12N 5/00
G01N 33/53
US Classification:
4241301, 435325, 435 71, 5303871
Abstract:
The present invention relates to methods and compositions for modulating platelet activity, and methods and compositions for treating a disease or disorder associated with platelet activity in a subject, comprising administering a single chain anti-TREM-like transcript-1 (TLT-1) antibody or a functional fragment or variant thereof in an amount effective to modulate platelet activity.