Resumes
Resumes
Ayodele Ogunkoya Phones & Addresses
-
Berkeley, CA
Publications
Us Patents
Camptothecine Antibody-Drug Conjugates And Methods Of Use Thereof
View pageUS Patent:
20220241423, Aug 4, 2022
Filed:
Jan 13, 2022
Appl. No.:
17/575481
Inventors:
- Carson City NV, US
Ayodele O. Ogunkoya - Berkeley CA, US
Penelope M. Drake - Castro Valley CA, US
Ayodele O. Ogunkoya - Berkeley CA, US
Penelope M. Drake - Castro Valley CA, US
International Classification:
A61K 47/54
A61K 47/64
A61K 47/64
Abstract:
The present disclosure provides antibody-drug conjugate (ADC) structures, which include a camptothecine or a camptothecine derivative linked to a polypeptide (e.g., an antibody) through a linker. The disclosure also encompasses compounds and methods for production of such conjugates, as well as methods of using the conjugates.
Glycoside-Containing Peptide Linkers For Antibody-Drug Conjugates
View pageUS Patent:
20220226490, Jul 21, 2022
Filed:
Jan 22, 2020
Appl. No.:
17/423796
Inventors:
- Carson City NV, US
Junjie Liu - San Diego CA, US
Ayodele Ogunkoya - Berkeley CA, US
Junjie Liu - San Diego CA, US
Ayodele Ogunkoya - Berkeley CA, US
International Classification:
A61K 47/68
A61P 35/00
A61P 35/00
Abstract:
The present disclosure provides antibody-drug conjugate structures, which include a cleavable linker that links the antibody to the drug and has a first cleavable moiety and a second cleavable moiety that hinders cleavage of the first cleavable moiety. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.