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Asmamaw T Wassie

from Leander, TX
Age ~34
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Also known as:
Asmamaw S
Related to:
Thomas B Wassie, 66Tsegaye W Teferi, 66
Connected to:
Fetsum M Wassie, 57Michael S Wassief, 41Ellen S Wassif, 44Kimberly S Wassik, 62Gerald J Wassil, 74Kirstin A Wassil, 44Armand Wassilian, 35Kip M Wassink, 48Lloyd H Wassink, 86Marco G Wassink, 48

Asmamaw Wassie Phones & Addresses

  • Leander, TX
  • Cambridge, MA
  • Boston, MA
  • Campbell, CA

Resumes

Resumes

Asmamaw Wassie Photo 1

Scientific Director

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Location:
Cambridge, MA
Work:
Mitolab
Scientific Director
Education:
Massachusetts Institute of Technology 2013 - 2019
Doctorates, Doctor of Philosophy, Philosophy
Asmamaw Wassie Photo 2

Student At Massachusetts Institute Of Technology

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Location:
Greater Boston Area
Industry:
Biotechnology
Education:
Massachusetts Institute of Technology 2008 - 2012

Publications

Us Patents

Iterative Direct Expansion Microscopy

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US Patent:
20200271556, Aug 27, 2020
Filed:
Feb 19, 2020
Appl. No.:
16/794849
Inventors:
- Cambridge MA, US
Edward Stuart Boyden - Chestnut Hill MA, US
Asmamaw T. Wassie - Boston MA, US
Jinyoung Kang - Cambridge MA, US
International Classification:
G01N 1/36
G01N 1/28
Abstract:
The present invention provides biological samples of interest that have been iteratively expanded in a method referred to herein as iterative direct expansion microscopy (id-ExM). In the id-ExM method, biological samples of interest are permeated with a swellable material that results in the sample becoming embedded in the swellable material, and then the sample can be expanded isotropically in three dimensions. The process of iteratively expanding the samples can be applied to expand samples one or more additional times such that, for example, a 5-fold expanded sample can be expanded again to achieve high expansion factors, for example, 20× to 100× or more linear expansion.

Single-Molecule Protein And Peptide Sequencing

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US Patent:
20200217853, Jul 9, 2020
Filed:
Jan 7, 2020
Appl. No.:
16/736248
Inventors:
- Cambridge MA, US
Alexi Georges Choueiri - Chandler AZ, US
Edward Stuart Boyden - Chestnut Hill MA, US
Asmamaw Wassie - Boston MA, US
International Classification:
G01N 33/68
G01N 33/58
Abstract:
The present description provides methods, assays and reagents useful for sequencing proteins. Sequencing proteins in a broad sense involves observing the plausible identity and order of amino acids, which is useful for sequencing single polypeptide molecules or multiple molecules of a single polypeptide. In one aspect, the methods are useful for sequencing multiple polypeptides. The methods and reagents described herein can be useful for high resolution interrogation of the proteome and enabling ultrasensitive diagnostics critical for early detection of diseases.

Multiplexed Signal Amplified Fish Via Splinted Ligation Amplification And Sequencing

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US Patent:
20180216161, Aug 2, 2018
Filed:
Jan 22, 2018
Appl. No.:
15/876347
Inventors:
- Cambridge MA, US
Asmamaw T. Wassie - Boston MA, US
Shahar Alon - Cambridge MA, US
Adam Henry Marblestone - Arlington MA, US
Anubhav Sinha - Cambridge MA, US
Andrew Payne - Cambridge MA, US
Edward Stuart Boyden - Chestnut Hill MA, US
International Classification:
C12Q 1/6806
C12Q 1/6811
C12Q 1/682
C12Q 1/6855
Abstract:
The present invention relates to a method for amplifying at least one target RNA in a fixed and, optionally, expanded biological sample. In an embodiment of the invention, the method comprises incubating the fixed biological sample with a pair of polynucleotides complementary to non-overlapping and proximal sequences of a target RNA, wherein the polynucleotide pair hybridizes to the target RNA; ligating the polynucleotide pair using a ligase; and amplifying the ligation product. The invention further provides methods for detecting and optionally quantifying and/or sequencing the amplification product. As the method comprises hybridizing polynucleotide pairs to a target RNA in a fixed biological sample, the target RNA can be hybridized in situ.

Augmenting In Situ Nucleic Acid Sequencing Of Expanded Biological Samples With In Vitro Sequence Information

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US Patent:
20180119219, May 3, 2018
Filed:
Oct 20, 2017
Appl. No.:
15/789419
Inventors:
- Cambridge MA, US
Shahar Alon - Cambridge MA, US
Andrew Payne - Cambridge MA, US
Asmamaw Wassie - Boston MA, US
Daniel Goodwin - Somerville MA, US
Edward Stuart Boyden - Chestnut Hill MA, US
International Classification:
C12Q 1/6874
Abstract:
The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids in a process referred to herein as “expansion sequencing” (ExSEQ).

Stochastic Arrangement Of Reagents In Clusters - Starc

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US Patent:
20160305939, Oct 20, 2016
Filed:
Apr 14, 2016
Appl. No.:
15/099248
Inventors:
- Cambridge MA, US
Asmamaw Wassie - Cambridge MA, US
Chih-Chieh Yu - Cambridge MA, US
Edward Boyden - Cambridge MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
G01N 33/566
Abstract:
The invention, in some aspects relates to compositions and methods for imaging biological systems and physiological activity and conditions in cells.

Methods And Apparatus For Artificial Olfaction

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US Patent:
20150362469, Dec 17, 2015
Filed:
Jul 31, 2015
Appl. No.:
14/815574
Inventors:
Asmamaw Wassie - Cambridge MA, US
Yael Maguire - Boston MA, US
David Kong - Lexington MA, US
Shuguang Zhang - Cambridge MA, US
Patrick Moran - Shrewsbury MA, US
Karolina Corin - Johannesburg, ZA
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
G01N 33/00
Abstract:
In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents.

Methods And Apparatus For Artificial Olfaction

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US Patent:
20140099729, Apr 10, 2014
Filed:
Aug 13, 2013
Appl. No.:
13/966169
Inventors:
Asmamaw Wassie - Cambridge MA, US
Yael Maguire - Boston MA, US
David Kong - Lexington MA, US
Shuguang Zhang - Cambridge MA, US
Patrick Moran - Shrewsbury MA, US
Karolina Corin - Johannesburg, ZA
International Classification:
G01N 33/00
US Classification:
436149, 422 83, 422 98
Abstract:
In exemplary implementations of this invention, an electronic olfactor determines whether a scent being tested matches the scent of a positive control. The electronic olfactor can perform this scent matching even in a changing olfactory environment, and even if the positive control scent is a combination of hundreds or thousands of different odorants. No prior training is needed, and no attempt is made to identify a single odorant that is unambiguously responsible for a scent. Instead, a computer compares the total scent pattern of a positive control sample with the total scent pattern of a test sample, across a sweep of many permutations of electrical inputs to scent sensors, to try to find any condition under which the total scent patterns do not match. If such a condition cannot be found, then the computer declares a match between the test and target scents.
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Asmamaw T Wassie from Leander, TX, age ~34 Get Report