Inventors:
Archil Shartava - Mobile AL
Assignee:
South Alabama Medical Science Foundation - Mobile AL
International Classification:
A01N 102
A01N 6300
A01N 3712
Abstract:
The invention provides a method of preserving red blood cells. The method comprises treating the red blood cells with about 2 mM to about 35 mM of N-acetylcysteine. The invention further provides a method of aging red blood cells. This method comprises isolating red blood cells; incubating the isolated red blood cells at about 37. degree. C. ; and cyclically exposing the incubated red blood cells to N. sub. 2 for about 15 minutes then to ambient air for about 5 minutes for a total of about 16 hours. This method allows for the timely screening of agents for their ability to affect the premature aging of red blood cells. This timely screening can be conducted in the course of 16 hours as opposed to weeks or months that would be necessary if the red cells could not be prematurely aged in accordance with the method of the subject invention.
