Inventors:
Richard M. Weinshilboum - Rochester MN, US
Eric O. Wieben - Rochester MN, US
Oreste Salavaggione - St. Louis MO, US
Araba A. Adjei - Rochester MN, US
Linda Pelleymounter - Rochester MN, US
Josefa Coronel - Union City CA, US
Liewei Wang - Rochester MN, US
Bruce Eckloff - Oronoco MN, US
Daniel Schaid - Rochester MN, US
Cynthia X. Ma - Ladue MO, US
Assignee:
Mayo Foundation for Medical Education and Research - Rochester MN
International Classification:
C07H 21/04
C12P 19/34
C12Q 1/68
Abstract:
Isolated CYP19A1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as CYP19A1 allozymes. Methods for determining the aromatase status of an individual also are provided, as are methods for determining if a subject is predisposed to certain clinical conditions.