Anthony J Makarewicz

6368557, Apr 9, 2002

Dec 30, 1998

09/223685

Alec A. Piplani - Mountain View CA
Anthony Makarewicz - Dublin CA
Jean-Pierre Dueri - Sunnyvale CA
Thomas A. Afzal - Menlo Park CA

Cardiovention, Inc. - Santa Clara CA

A61M 114

422 45, 604 609, 604 611

Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to prevent microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to minimize flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements. Blood trauma may be further reduced by contouring the vanes and other components of the device.

6379618, Apr 30, 2002

Dec 30, 1998

09/223676

Alec A. Piplani - Mountain View CA
Anthony Makarewicz - Dublin CA
Jean-Pierre Dueri - Sunnyvale CA
Thomas A. Afzal - Menlo Park CA

Cardiovention, Inc. - Santa Clara CA

A61M 114

422 45, 422 48, 604 611, 604 614, 96257

Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. A plurality of vanes arranged along a central shaft of the device increase pressure near the center of the fiber bundle to prevent microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to minimize flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements. Blood trauma may be further reduced by contouring the vanes and other components of the device.

6491685, Dec 10, 2002

Mar 1, 2000

09/516999

Steven R. Visuri - Livermore CA
Anthony J. Makarewicz - San Ramon CA
Richard A. London - Orinda CA
William J. Benett - Livermore CA
Peter Krulevitch - Pleasanton CA
Luiz B. Da Silva - Pleasanton CA

The Regents of the University of California - Oakland CA

A61B 1722

606 25, 606128

An acoustic focusing device whose acoustic waves are generated by laser radiation through an optical fiber. The acoustic energy is capable of efficient destruction of renal and biliary calculi and deliverable to the site of the calculi via an endoscopic procedure. The device includes a transducer tip attached to the distal end of an optical fiber through which laser energy is directed. The transducer tip encapsulates an exogenous absorbing dye. Under proper irradiation conditions (high absorbed energy density, short pulse duration) a stress wave is produced via thermoelastic expansion of the absorber for the destruction of the calculi. The transducer tip can be configured into an acoustic lens such that the transmitted acoustic wave is shaped or focused. Also, compressive stress waves can be reflected off a high density/low density interface to invert the compressive wave into a tensile stress wave, and tensile stresses may be more effective in some instances in disrupting material as most materials are weaker in tension than compression. Estimations indicate that stress amplitudes provided by this device can be magnified more than 100 times, greatly improving the efficiency of optical energy for targeted material destruction.

6503450, Jan 7, 2003

Dec 30, 1999

09/475467

Thomas A. Afzal - Menlo Park CA
Jean-Pierre Dueri - Sunnyvale CA
Alex Leynov - Walnut Creek CA
Anthony Makarewicz - Dublin CA
Alec A. Piplani - Mountain View CA
Greg Potts - Mountain View CA

Cardiovention, Inc. - Santa Clara CA

A61M 114

422 45, 422 48, 604 401, 604 611, 604 613, 604 614, 96257

Improvements to integrated blood pump/oxygenator having a rotating hollow fiber bundle assembly that both oxygenates and pumps blood are provided. An inner member arranged along a central axis of the device accelerates blood entering the fiber bundle to reduce microbubble generation and blood trauma. Shearing loads imposed on the fiber elements of the fiber bundle are reduced by the addition of a reinforcement structure, while the gas flow path is configured to reduce flooding and loss of oxygenation efficiency due to occasional rupture of fiber elements.

7412356, Aug 12, 2008

Jan 30, 2007

11/700686

John M. Dzenitis - Danville CA, US
Claudia K. Hertzog - Houston TX, US
Anthony J. Makarewicz - Livermore CA, US
Bruce D. Henderer - Livermore CA, US
Vincent J. Riot - Oakland CA, US

Lawrence Livermore National Security, LLC - Livermore CA

G06F 19/00
G06F 17/40

702189, 702 1, 702 19, 702 22, 702 85, 702104, 702127, 702187, 702190, 702191, 702193

A method of detecting real events by obtaining a set of recent signal results, calculating measures of the noise or variation based on the set of recent signal results, calculating an expected baseline value based on the set of recent signal results, determining sample deviation, calculating an allowable deviation by multiplying the sample deviation by a threshold factor, setting an alarm threshold from the baseline value plus or minus the allowable deviation, and determining whether the signal results exceed the alarm threshold.

20060057599, Mar 16, 2006

Nov 29, 2004

11/000491

John Dzenitis - Danville CA, US
Steve Brown - Livermore CA, US
Billy Colston - San Ramon CA, US
Dora Gutierrez - Livermore CA, US
Bruce Henderer - Livermore CA, US
Benjamin Hindson - Belmont, AU
Ramakrishna Madabhushi - Fremont CA, US
Anthony Makarewicz - Livermore CA, US
Don Masquelier - Tracy CA, US
Mary McBride - Brentwood CA, US
Thomas Metz - Tracy CA, US
Shanavaz Nasarabadi - Livermore CA, US
Ujwal Setlur - Livermore CA, US
Sally Smith - Salida CA, US
Kodumudi Venkateswaran - Livermore CA, US

C12Q 1/68
C12M 1/34

435006000, 435030000, 435287200, 435288500

An autonomous monitoring apparatus for monitoring air, water, soil, or other substance for bioagents. A collector gathers a quantity of the air, water, soil, or other substance being monitored. A sample preparation system prepares a sample of the selected potential bioagent particles. The sample is analyzed by a system for detecting said bioagents.

20080025871, Jan 31, 2008

Jul 27, 2006

11/495952

John M. Dzenitis - Danville CA, US
Benjamin J. Hindson - Belmont, AU
Anthony J. Makarewicz - Livermore CA, US
William J. Benett - Livermore CA, US
Aaron M. Mason - Wilmington MA, US
Paul B. Haigh - Wilmington MA, US

B01L 3/00
G01N 21/00

422 55, 422 99

A system for maintaining a liquid slurry of microbeads for use in biological or chemical analysis comprising providing a flexible bag and filling the flexible bag with a slurry of a liquid and microbeads. One embodiment is an apparatus for maintaining liquid slurries of particles for use in biological or chemical analysis comprising a bag, a liquid contained within the bag, and particles contained within the liquid in the bag.

20090074628, Mar 19, 2009

Sep 18, 2007

11/901787

William J. Benett - Livermore CA, US
John T. Andreski - Tracy CA, US
John M. Dzenitis - Danville CA, US
Anthony J. Makarewicz - Livermore CA, US
Dean R. Hadley - Manteca CA, US
Satinderpall S. Pannu - Pleasanton CA, US

B01J 19/00
B21D 53/02
C12M 1/38
B01L 7/00

422138, 422131, 422307, 4352851, 4352861, 422132, 2989003

A thermalcycler includes a first thermalcycler body section having a first face and a second thermalcycler body section having a second face. A cavity is formed by the first face and the second face. A thermalcycling unit is positioned in the cavity. A heater trace unit is connected to a support section, to the first thermalcycler body section, to the second thermalcycler body section, and to the thermalcycling unit. The first thermalcycler body section and the second thermalcycler body section are positioned together against the support section to enclose the thermalcycling unit and the heater trace unit.