Inventors:
Umesh B. Gangadharmath - Los Angeles CA, US
Hartmuth C. Kolb - Playa Del Rey CA, US
Peter J. H. Scott - Ypsilanti MI, US
Joseph C. Walsh - Pacific Palisades CA, US
Wei Zhang - Los Angeles CA, US
Anna Katrin Szardenings - Torrance CA, US
Anjana Sinha - San Diego CA, US
Gang Chen - Los Angeles CA, US
Eric Wang - San Diego CA, US
Chul Yu - Los Angeles CA, US
Changhui Liu - Los Angeles CA, US
Daniel Kurt Cashion - Manhattan Beach CA, US
Dhanalakshmi Kasi - Los Angeles CA, US
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 51/00
A61M 36/14
US Classification:
424 189, 424 111, 424 165, 424 181, 424 185
Abstract:
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.