Search

Ann Carol Palmenberg

from Madison, WI
Age ~76

Ann Palmenberg Phones & Addresses

  • 5010 Manor Cross, Madison, WI 53711 (608) 233-8629

Publications

Us Patents

Protein Inhibitor Of Ran Activity And Methods Of Use Thereof

View page
US Patent:
7741022, Jun 22, 2010
Filed:
Jan 18, 2007
Appl. No.:
11/654848
Inventors:
Frederick William Porter - Monona WI, US
Ann Carol Palmenberg - Madison WI, US
Christiane Wiese - Madison WI, US
Yury Alexandrovitch Bochkov - Madison WI, US
Assignee:
Wisconsin Alumi Research Foundation - Madison WI
International Classification:
C12Q 1/00
A61K 38/00
US Classification:
435 4, 530324
Abstract:
The invention provides a method of inhibiting Ran protein activity in at least one eukaryotic cell or cell-free extract, the method comprising exposing an amino acid sequence comprising at least a portion of EMCV or TMEV leader protein, wherein the amino acid sequence comprises SEQ. ID NO: 14 or SEQ. ID NO: 15, to at least one cell in an amount effective to inhibit Ran activity in the targeted cell and evaluating Ran protein activity in the cell.

Compositions And Methods For Regulating Mrna Transcription And Translation

View page
US Patent:
7947493, May 24, 2011
Filed:
Jul 9, 2004
Appl. No.:
10/888143
Inventors:
Ann C. Palmenberg - Madison WI, US
Aleksey G. Aminev - Fitchburg WI, US
Rachel P. Groppo - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12N 15/00
C12N 15/10
C12N 15/11
C12N 15/34
US Classification:
4353201, 435 691, 435 914, 536 231, 536 237, 536 241
Abstract:
The invention relates to compositions, specifically novel nucleic acid constructs encoding a cardiovirus 2A polypeptide operably linked to suitable promoters. Also, disclosed are methods whereby the nucleic acid constructs are introduced into cells or cell free systems to regulate cellular mRNA transcription and cap-dependent or internal ribosomal entry site (IRES)-dependent mRNA translation.

Full Genome Sequences Of Human Rhinovirus Strains

View page
US Patent:
20100233677, Sep 16, 2010
Filed:
Feb 9, 2010
Appl. No.:
12/703147
Inventors:
Stephen B. Liggett - Clarksville MD, US
Claire M. Fraser-Liggett - Clarksville MD, US
Ann C. Palmenberg - Madison WI, US
International Classification:
C12Q 1/70
US Classification:
435 5
Abstract:
Infection by human rhinovirus (HRV) causes upper and lower respiratory tract disease with varying degrees of virulence. The molecular basis of diversity was examined by completing the genome sequences for all known serotypes (n=99) as well as novel field samples. Superimposition of capsid crystal structure and optimal-energy RNA configurations established the alignments. The phylogeny revealed conserved motifs, Glade-specific diversity including a potential new species (clade-D), pan-genome mutations in field isolates, and unexpected recombination that contributes to heterogeneity. A spacer tract near a 5′-UTR cloverleaf was hypervariable, and in analogy with poliovirus, may be associated with virulence. A previously unidentified configuration consistent with non-scanning internal ribosome entry may account for rapid protein translation. The data density from complete sequences of the HRV reference serotypes provided high resolution for this degree of modeling, and serves as a platform for full genome-based epidemiologic studies, for viral diagnostics and prognostics, and for antiviral compounds and vaccines.

Translation Enhancer

View page
US Patent:
49371908, Jun 26, 1990
Filed:
Oct 15, 1987
Appl. No.:
7/109132
Inventors:
Ann C. Palmenberg - Madison WI
Gregory M. Duke - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12P 2100
C12P 1934
C12N 1500
US Classification:
435 691
Abstract:
Disclosed in this patent are DNA sequences, RNA sequences, vectors, and hosts that incorporate a translation enhancer region derived from the 5' non-coding region of a cardiovirus. The enhancer acts at the RNA level (as opposed to the DNA level) to enhance production of proteins in cell free media. Proteinaceous material which is produced will not have attached to it any undesired material from the enhancer sequence. The invention is especially useful to enable efficient production of selected viral proteins of picornoviruses.

Autocatalytic Cleavage Site And Use Thereof In A Protein Expression Vector

View page
US Patent:
59121670, Jun 15, 1999
Filed:
Jun 6, 1995
Appl. No.:
8/468790
Inventors:
Ann C. Palmenberg - Madison WI
Michael A. Hoffman - Shaker Heights OH
Harry Hahn - Madison WI
Lee R. Martin - Madison WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C12N 1509
C12N 700
C12N 1500
US Classification:
4353201
Abstract:
A nucleic acid construct comprising at least two copies of a nucleic acid sequence encoding an autocatalytic peptide cleavage site is disclosed. This site preferably comprises the amino acid sequence DX(D,E)XNPGP. A method of exposing an animal to an antigenic amino acid sequence is also disclosed.

Method Of Inhibiting Picornavirus Disease

View page
US Patent:
52291111, Jul 20, 1993
Filed:
Jan 31, 1991
Appl. No.:
7/648098
Inventors:
Ann C. Palmenberg - Madison WI
Gregory M. Duke - Madison WI
Jorge E. Osorio - Oregon WI
Assignee:
Wiscosnin Alumni Research Foundation - Madison WI
International Classification:
A61K 3912
C12N 1500
US Classification:
424 89
Abstract:
A method for inhibiting picornavirus disease in non-murine mammals is disclosed. A vaccine containing a live, recombinant, attenuated picornavirus with a shortened poly(C) tract is administered to the mammal. Preferably, the picornavirus in the vaccine is of the same genus as the disease-causing picornavirus and has a shortened poly(C) tract. The administration of the vaccine causes antibodies effective against the disease-causing picornavirus to be formed in vivo. In one embodiment of the invention, a vaccine containing Mengovirus with a shortened poly(C) tract can be used as a vaccine for both pigs and monkeys.

Methods Of Propagating Rhinovirus C In Previously Unsusceptible Cell Lines

View page
US Patent:
20190055521, Feb 21, 2019
Filed:
Mar 6, 2018
Appl. No.:
15/913058
Inventors:
- Madison WI, US
Yury A. Bochkov - Fitchburg WI, US
Ann C. Palmenberg - Madison WI, US
International Classification:
C12N 7/00
C07K 14/705
G01N 33/50
Abstract:
The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.

Methods Of Propagating Rhinovirus C In Previously Unsusceptible Cell Lines

View page
US Patent:
20170082609, Mar 23, 2017
Filed:
Aug 26, 2015
Appl. No.:
14/836327
Inventors:
- Madison WI, US
Yury A. Bochkov - Fitchburg WI, US
Ann C. Palmenberg - Madison WI, US
International Classification:
G01N 33/50
C12N 7/00
Abstract:
The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.

Wikipedia References

Ann Palmenberg Photo 1

Ann C . Palmenberg

Work:
Position:

President

Education:
Studied at:

University of Wisconsin - Madison • St. Lawrence University

Area of science:

Translation • Molecular biology

Academic degree:

Professor • PHD

Skills & Activities:
Skill:

Immunizations

Ann Carol Palmenberg from Madison, WI, age ~76 Get Report