Inventors:
Eckard Wimmer - E. Setauket NY, US
Jeronimo Cello - Port Jefferson NY, US
Aniko Paul - Setauket NY, US
Hidemi Toyoda - E. Setauket NY, US
Jiang Yin - Port Jefferson NY, US
Assignee:
The Research Foundation of State University of New York - Albany NY
International Classification:
A61K 39/12
C12P 19/33
Abstract:
A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2atumors) expressing CD155, the poliovirus receptor, and is effective for oncolytic treatment and cure of solid tumors, such as neuroblastoma.