US Patent:
20150210720, Jul 30, 2015
Inventors:
- North Chicago IL, US
Huaqing Liu - Buffalo Grove IL, US
Bruce Clapham - Lindenhurst IL, US
Ana L. Aguirre - Chicago IL, US
Marlon Cowart - Round Lake Beach IL, US
John R. Koenig - Chicago IL, US
Katerina Sarris - Mundelein IL, US
Marc J. Scanio - Lindenhurst IL, US
Kerren K. Swinger - Lexington MA, US
Anil Vasudevan - Union Grove WI, US
Clara I. Villamil - Glenview IL, US
Kevin R. Woller - Antioch IL, US
International Classification:
C07D 519/00
C07D 493/10
C07D 405/12
C07D 491/20
C07D 307/83
C07D 491/048
C07D 491/107
Abstract:
Compounds of formula (I)and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R, Z, Z, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
