Amy E Wilson

20030077701, Apr 24, 2003

Dec 20, 2001

10/029314

Carlos Forray - Paramus NJ, US
John Salon - Santa Paula CA, US
Thomas Laz - Parlin NJ, US
Raisa Nagorny - Fairlawn NY, US
Amy Wilson - Woodstock NY, US

C07K014/74
C07H021/04
C12P021/02
C12N005/06

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors. This invention provides a method of modifying the feeding behavior of a subject which comprises administering to the subject an amount of an MCH1 antagonist effective to decrease the body mass of the subject and/or decrease the consumption of food by the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of an MCH1 antagonist effective to treat the subject's depression and/or anxiety.

20030130493, Jul 10, 2003

Aug 26, 2002

10/228762

James Bonini - Oakland NJ, US
Ling Huang - Kearny NJ, US
Beth Borowsky - Flemington NJ, US
John Salon - Santa Paula CA, US
Amy Wilson - Woodstock NY, US
Raisa Nagorny - Fair Lawn NJ, US

C07H021/04
C12Q001/68
C07K014/705
C12P021/02
C12N005/06
A61K038/17

536/023500, 530/350000, 514/012000, 435/006000, 435/069100, 435/320100, 435/325000

This invention provides isolated nucleic acids encoding mammalian Edg7 receptors, purified mammalian Edg7 receptors, vectors comprising nucleic acid encoding mammalian Edg7 receptors, cells comprising such vectors, antibodies directed to mammalian Edg7 receptors, nucleic acid probes useful for detecting nucleic acid encoding mammalian Edg7 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian Edg7 receptors, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian Edg7 receptors, methods of isolating mammalian Edg7 receptors, methods of treating an abnormality that is linked to the activity of the mammalian Edg7 receptors, as well as methods of determining binding of compounds to mammalian Edg7 receptors, methods of identifying agonists and antagonists of Edg7 receptors, and agonists and antagonists so identified.

20030143670, Jul 31, 2003

Feb 20, 2002

10/080263

James Bonini - Oakland NJ, US
Amy Wilson - Woodstock NY, US

C12P021/02
C12N005/06
C07K014/705
C07H021/04

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

This invention provides isolated nucleic acids encoding mammalian SNORF44 receptor, purified mammalian SNORF44 receptor, vectors comprising nucleic acid encoding mammalian SNORF44 receptor, cells comprising such vectors, antibodies directed to mammalian SNORF44 receptor, nucleic acid probes useful for detecting nucleic acid encoding mammalian SNORF44 receptor, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding mammalian SNORF44 receptor, transgenic, nonhuman animals which express DNA encoding normal or mutant mammalian SNORF44 receptor, and methods of isolating mammalian SNORF44 receptor. This invention also provides methods of treating an abnormality that is linked to the activity of a mammalian SNORF44 receptor, as well as methods of determining binding of compounds to a mammalian SNORF44 receptor, methods of identifying agonists and antagonists of a SNORF44 receptor, and agonists and antagonists so identified.

62216139, Apr 24, 2001

Dec 31, 1998

9/224426

John A. Salon - Montclair NJ
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - New York NY

Synaptic Pharmaceutical Corporation - Paramus NJ

G01N 3353

435 71

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

62911953, Sep 18, 2001

Jan 6, 2000

9/478602

John A. Salon - Montclair NJ
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - New York NY

Synaptic Pharmaceutical Corporation - Paramus NJ

G01N 3353

435 721

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

62216163, Apr 24, 2001

Jan 6, 2000

9/478601

John A. Salon - Montclair NJ
Thomas M. Laz - Parlin NJ
Raisa Nagorny - Fair Lawn NJ
Amy E. Wilson - New York NY

Synaptic Pharmaceutical Corporation - Paramus NJ

G01N 3353

435 71

This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense oligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.