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Amr A Abdeen

from Madison, WI
Age ~37
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Connected to:
Adnan M Abdeen, 89Firas M Abdeen, 30Moutaz H Abdeen, 53Ola O Abdeen, 53Susan P Abdeen, 50David M Abdehou, 69Amr Abdel, 50Frank A Abdel, 55Mona I Abdel, 40Heba A Abdelaal, 36

Amr Abdeen Phones & Addresses

  • Madison, WI
  • Urbana, IL

Work

Company: University of wisconsin-madison Sep 2016 Position: Postdoctoral research associate

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Illinois at Urbana - Champaign 2011 to 2016 Specialities: Philosophy

Resumes

Resumes

Amr Abdeen Photo 1

Postdoctoral Research Associate

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Location:
Madison, WI
Work:
University of Wisconsin-Madison
Postdoctoral Research Associate
Education:
University of Illinois at Urbana - Champaign 2011 - 2016
Doctorates, Doctor of Philosophy, Philosophy

Publications

Us Patents

Polyplex Delivery System For Proteins, Nucleic Acids And Protein/Nucleic Acid Complexes

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US Patent:
20190307888, Oct 10, 2019
Filed:
Feb 21, 2019
Appl. No.:
16/282174
Inventors:
- Madison WI, US
Yuyuan WANG - Madison WI, US
Krishanu SAHA - Middleton WI, US
Amr Ashraf ABDEEN - Madison WI, US
International Classification:
A61K 47/59
A61K 47/61
A61K 49/00
A61K 51/06
A61K 38/46
A61K 31/7105
Abstract:
Provided herein are nanoplexes comprising a payload selected from a protein and/or a polynucleic acid; and a plurality of copolymers comprising a first copolymer that is poly(N,N′-bis(acryloyl)cystamine-poly(aminoalkyl)) (PBAP), a second copolymer that is poly(Cakylene glycol)-PBAP-poly(Cakylene glycol), and a third copolymer that is TG-poly(Cakylene glycol)-PBAP-poly(Cakylene glycol)-TG wherein TG at each occurrence is independently a targeting ligand, a cell penetrating peptide, an imaging agent or a capping group, provided that a plurality of TG groups is a targeting ligand; wherein the payload is non-covalently complexed to one or more of the copolymers, one or more of the first, second, and/or third copolymers comprises an endosomal escape group having a pKa of about 4.5 to about 6.5, and optionally one or more of the first, second, and/or third copolymers comprises a host and a guest non-covalent crosslinker.

Nanocapsule Delivery System For Ribonucleoproteins

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US Patent:
20190099381, Apr 4, 2019
Filed:
Aug 27, 2018
Appl. No.:
16/113963
Inventors:
- Madison WI, US
Amr ABDEEN - Madison WI, US
Krishanu SAHA - Madison WI, US
Yuyuan WANG - Madison WI, US
Ruosen XIE - Madison WI, US
International Classification:
A61K 9/51
C12N 15/11
C12N 9/22
C12N 15/90
A61K 9/50
Abstract:
Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.

Modified Guide Rnas, Crispr-Ribonucleotprotein Complexes And Methods Of Use

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US Patent:
20180362971, Dec 20, 2018
Filed:
Jun 14, 2018
Appl. No.:
16/008376
Inventors:
- MADISON WI, US
Krishanu Saha - Middleton WI, US
Amr Ashraf Abdeen - Madison WI, US
Lucille Katherine Kohlenberg - Madison WI, US
International Classification:
C12N 15/11
C12N 9/22
C12N 15/90
Abstract:
Described herein are modified guide RNAs such as a single guide RNA including, from 5′ to 3′, a single-stranded protospacer sequence, a first complementary strand of a binding region for the Cas9 polypeptide, an aptamer that binds a biotin-binding molecule, and a second complementary strand of the binding region for the Cas9 polypeptide. Also described is an RNP complex including the modified guide RNA and a Cas9 polypeptide or active fragment thereof. Also included are methods of modifying target genes in cells using the modified guide RNAs.
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Amr A Abdeen from Madison, WI, age ~37 Get Report