Inventors:
Edward R. Bacon - Audubon PA, US
Thomas R. Bailey - Phoenixville PA, US
Nadine C. Becknell - Coatesville PA, US
Sankar Chatterjee - Wynnewood PA, US
Derek Dunn - Coatesville PA, US
Greg A. Hostetler - Newark DE, US
Robert L. Hudkins - Chester Springs PA, US
Kurt A. Josef - Radnor PA, US
Lars J. S. Knutsen - West Chester PA, US
Ming Tao - Maple Glen PA, US
Allison L. Zulli - Wayne PA, US
Assignee:
Cephalon, Inc. - Frazer PA
International Classification:
C07D 403/12
C07D 401/14
A61K 31/501
A61P 25/20
A61P 3/04
A61P 25/18
A61P 29/00
A61P 25/06
A61P 25/24
A61P 25/08
US Classification:
51425203, 51425205, 544238
Abstract:
The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds and/or their pharmaceutically acceptable salts may be effective in the treatment of diseases or disease states related to the activity of the histamine Hreceptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.