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Alfred A Stracher

from New York, NY
Age ~94
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Also known as:
Alfred D Stracher, Alfred R Stracher, Dorothy A Stracher, Stracher Stracher, Leo Kesner
Related to:
Simon R Stracher, 29
Connected to:
Dorothy A Stracher, 90Suzanne J Strache, 55Adrienne D Strachn, 66Brittany P Strachota, 32Elizabeth J Strachota, 41Lisa M Strachota, 63Rose M Strachn, 67Trevor A Strachn, 61Amy L Strackbein, 45Carl A Stracka, 100

Alfred Stracher Phones & Addresses

  • New York, NY
  • 20 Sidney St, Woods Hole, MA 02543 (508) 540-1755
  • Falmouth, MA
  • 27010 Grand Central Pkwy APT 28A, Floral Park, NY 11005 (212) 996-5056
  • 47 The Oaks, Roslyn, NY 11576 (516) 484-0189 (516) 621-5674

Work

Company: Suny downstate medical center Position: Distinguished professor of physiol/pharmacology

Industries

Hospital & Health Care

Resumes

Resumes

Alfred Stracher Photo 1

Distinguished Professor Of Physiol And Pharmacology

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Location:
New York, NY
Industry:
Hospital & Health Care
Work:
SUNY Downstate Medical Center
Distinguished Professor of Physiol/Pharmacology

Business Records

Name / Title
Company / Classification
Phones & Addresses
Alfred Stracher
Chief Executive Officer
Protor Pharma Corp
Commercial Physical Research
17 Spg Hl Dr, Town Center, NJ 07052

Publications

Us Patents

Treatment Of Multiple Sclerosis And Other Autoimmune Diseases By Use Of Calpin Inhibitors

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US Patent:
7968516, Jun 28, 2011
Filed:
Sep 29, 2005
Appl. No.:
11/663666
Inventors:
Alfred Stracher - Roslyn NY, US
Leo Kesner - West Orange NJ, US
Assignee:
ProTor Pharma Corporation - Roslyn NY
International Classification:
A61K 38/06
A61K 38/00
US Classification:
514 179, 514 219
Abstract:
Described herein are compounds and methods for treating or preventing a neurologic, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as therapeutics.

Compositions, And Kits Comprising Targeted Aldehyde Or Acetal Protease Inhibitor Compounds For Treating Muscle Disorders

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US Patent:
20080039531, Feb 14, 2008
Filed:
Dec 28, 2005
Appl. No.:
11/321782
Inventors:
Alfred Stracher - Roslyn NY, US
Leo Kesner - West Orange NJ, US
Ted Carver - Charlotte NC, US
Norman Barton - Phoenix MD, US
International Classification:
A61K 31/11
A61P 21/00
US Classification:
514693000
Abstract:
Described herein are compounds that comprise a carrier residue that is or is an analog of carnitine, an optional linker group, and a residue of a protease inhibitor comprising an aldehyde group or acetal derivatives of the aldehyde group, and pharmaceutical compositions and kits thereof. The compounds, compositions, and kits are useful for treating muscle disorders in animals and humans that result from the undesired activity of biological proteases. The compounds of the invention are particularly effective as calpain inhibitors, and can be used to treat the resulting muscular disorders, exemplified by Duchenne or Becker muscular dystrophy.

Targeted Delivery Of Pharmaceutical Compounds

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US Patent:
20090227522, Sep 10, 2009
Filed:
Feb 28, 2007
Appl. No.:
12/280844
Inventors:
Alfred Stracher - Roslyn NY, US
Leo Kessner - West Orange NJ, US
Abraham Shulman - Hollis Hills NY, US
International Classification:
A61K 38/05
C07C 233/47
A61P 25/28
US Classification:
514 19, 564197
Abstract:
Techniques are provided for targeting a pharmaceutically active compound using, as a carrier, a molecule (or molecules) having greater affinity for a particular site in a living organism's body than for other sites therein. A compound of the formula B-L-A is provided, where B represents the residue of a small synthetic molecule, preferably one that is approved for human use, having a greater affinity for a particular site in a patient's body than for other sites in the patient's body, L represents a direct bond or a linking group, and A represents the residue of a pharmaceutically active compound.

Treatment Of Traumatic Or Degenerative Neurologic, Otologic, Or Ophthalmologic Diseases With Targeted Protease Inhibitors

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US Patent:
20120135915, May 31, 2012
Filed:
Jun 27, 2011
Appl. No.:
13/170053
Inventors:
Alfred Stracher - Roslyn NY, US
Leo Kesner - West Orange NJ, US
Ted Carver - Charlotte NC, US
Norman W. Barton - Phoenix MD, US
International Classification:
A61K 38/06
A61P 25/00
US Classification:
514 13, 514 177
Abstract:
Described herein are compounds and methods for treating or preventing a neurologic, otologic, or ophthalmologic disease in a subject. Also described herein are compounds that can be used as therapeutics.

Carnitine Directed Pharmaceutical Agents

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US Patent:
50082884, Apr 16, 1991
Filed:
May 4, 1989
Appl. No.:
7/347361
Inventors:
Alfred Stracher - Roslyn Estates NY
Leo Kesner - Brooklyn NY
International Classification:
A61K 3124
A61K 3144
A61K 3702
C07K 1702
US Classification:
514535
Abstract:
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e. g. skeletal muscle or the heart. The pharmaceutically active compound can be a protease inhibitor, a cardioactive drug for combating arrythmia, etc. The linkage is chemical through one or more alcohol, carboxyl or amine groups using reagents such as glutaraldehyde, dicarboxylic acid anhydrides and acid halides and carbodiimides. Carnitine derivatives are also incorporated into liposomes which are then used as carriers of active pharmaceutical agents.

Carnitine Coupled Pharmaceutical Agents

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US Patent:
47420812, May 3, 1988
Filed:
Jan 6, 1986
Appl. No.:
6/816546
Inventors:
Alfred Stracher - Roslyn Estates NY
Leo Kesner - Brooklyn NY
International Classification:
A61K 31225
US Classification:
514547
Abstract:
Carnitine, which preferentially accumulates in cardiac and skeletal muscle, is coupled to a protease inhibitor, or any other pharmaceutically active compound for the purpose of site-specific drug delivery to these tissues. These products may be useful in a variety of muscle wasting diseases. They may also be useful in a variety of cardiac conditions including those produced by cardiac ischemia. They may also be useful as growth promoters for animals.

Hypoglycemic And Growth-Promoting Polypeptides Isolated From Bacitracin

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US Patent:
50700740, Dec 3, 1991
Filed:
Jul 23, 1990
Appl. No.:
7/559445
Inventors:
Victor Medina - Bayside NY
Alfred Stracher - Roslyn Estates NY
Leo Kesner - Brooklyn NY
Assignee:
Protor Co. - Garden City NY
International Classification:
A61K 3702
A61K 3726
C07C10352
US Classification:
514 3
Abstract:
This application discloses an invention comprising a polypeptide fraction isolated from commercial bacitracin and which contains most if not all of the anti-insulinase activity of bacitracin while exhibiting few if any of the antibacterial properties. The invention herein described also involves the use of this polypeptide fraction given orally or if given parenterally either together (as composite) or in sequence as a means of treating diabetics. For such purposes, the insulin and anti-insulinase polypeptide fraction may be used as separate substances or chemically linked by a wide variety of chemical linking agents well known in the art. In addition to clinical uses, the application describes a method of using the polypeptide fraction as a growth promoter substance to be added to animal feed and also a composition useful for this purpose.

Liposome Preferentially Traveling To Cardiac And Skeletal Muscles

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US Patent:
58767479, Mar 2, 1999
Filed:
Jul 8, 1992
Appl. No.:
7/912068
Inventors:
Alfred Stracher - Roslyn Estates NY
Leo Kesner - Brooklyn NY
International Classification:
A61K 9127
A61K 31685
US Classification:
424450
Abstract:
Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e. g. skeletal muscle or the heart. The pharmaceutically active compound can be a protease inhibitor, a cardioactive drug for combating arrythmia, etc. The linkage is chemical through one or more alcohol, carboxyl or amine groups using reagents such as glutaraldehyde, dicarboxylic acid anhydrides and acid halides and carbodiimides. Carnitine derivatives are also incorporated into liposomes which are then used as carriers of active pharmaceutical agents.

Isbn (Books And Publications)

Muscle and Nonmuscle Motility

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Author

Alfred Stracher

ISBN #

0126730016

Muscle and Nonmuscle Motility

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Author

Alfred Stracher

ISBN #

0126730024

Control profile
Alfred A Stracher from New York, NY, age ~94 Get Report