Inventors:
Charles G. ARNOLD - Kinnelon NJ, US
Agis KYDONIEUS - Kendall Park NJ, US
Thomas M. ROSSI - Stockton NJ, US
Alfred F. ALTOMARI - Lawrenceville NJ, US
International Classification:
A61K 31/567
Abstract:
A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.