Alfonso J Tobia

8629302, Jan 14, 2014

Sep 15, 2010

13/496340

Alfonso J. Tobia - Doylestown PA, US
Bernard E. Cabana - Biglerville PA, US
Venkata Vadlapatla - Paoli PA, US
Ronald H. Connolly - Philadelphia PA, US

C07C 45/61
C07C 45/81

568315, 568324

The present invention provides a method for making hypericin comprising the steps of converting a protohypericin to a protohypericin salt, and irradiating the protohypericin salt with visible light to form hypericin. The present invention also provides an apparatus comprising a transparent column having a top end and a bottom end, an inlet attached to the column at the top end to flow reactants into the column, a container attached to the column at the bottom end; and a visible light source positioned to cast light on to the column. The present invention further provides a method for making hypericin using said apparatus.

20130211371, Aug 15, 2013

Apr 20, 2011

13/695902

Alfonso J. Tobia - Doylestown PA, US
Bernard E. Cabana - Biglerville PA, US
Alain H. Rook - Wynnewood PA, US

Hy Biopharma, Inc. - Jamison PA

A61N 5/06

604501, 514680, 514455

A liquid or ointment formulation for the treatment of a skin condition associated with leukocyte accumulation in the skin includes a therapeutic compound selected to reduce leukocyte accumulation in the skin and an aqueous solution of an organic solvent. The organic solvent increases skin permeability. A method of treating a skin condition associated with leukocyte accumulation in the skin includes the steps of applying topically a liquid formulation of a photosensitizer to a skin lesion of a patient afflicted with the skin condition and exposing the skin lesion to a light source.

46721169, Jun 9, 1987

Dec 20, 1985

6/811233

Victor T. Bandurco - Bridgewater NJ
Stanley C. Bell - Narberth PA
John H. Dodd - Lebanon NJ
Robert Falotico - Belle Mead NJ
Charles F. Schwender - Califon NJ
Alfonso J. Tobia - Doylestown PA

Ortho Pharmaceutical Corporation - Raritan NJ

C07D23980

544286

Quinazoline derivatives having an oxy substituent in 5 and 6 positions are described. The novel quinazoline derivatives are useful as cardiotonic agents.

60018828, Dec 14, 1999

Jul 3, 1997

8/887546

Floyd Eliot Fox - Bellmawr NJ
Alain H. Rook - Wynnewood PA
Alfonso J. Tobia - Doylestown PA

The Trustees of the University of Pennsylvania - Philadelphia PA

A61K 3112

514680

The invention provides methods of using photoactivated hypericin compounds which, when photoactivated using visible or UV-A light, are useful for treating numerous diseases and disorders in mammals. The compounds of the invention are useful for inhibiting the proliferation and accumulation of mammalian leukocytes and for inducing apoptosis in mammalian leukocytes.

48228001, Apr 18, 1989

Jun 9, 1986

6/871967

Robert Falotico - Belle Mead NJ
Ramesh M. Kanojia - Somerville NJ
Jeffery B. Press - Rocky Hill NJ
Alfonso J. Tobia - Doylestown PA

Ortho Pharmaceutical Corporation - Raritan NJ

A61K 3147
C07D21724

514309

Substituted 3-isoquinolinol compounds of the general formula ##STR1## that exhibit cardiotonic, renal vasodilating and phosphodiesterase fraction III properties are pharmacologically active in the treatment of cardiac conditions. Methods for synthesizing and using those compounds are described.

47118830, Dec 8, 1987

Sep 30, 1985

6/782241

Victor T. Bandurco - Bridgewater NJ
Charles F. Schwender - Califon NJ
Robert Falotico - Belle Mead NJ
Alfonso J. Tobia - Doylestown PA

Ortho Pharmaceutical Corporation - Raritan NJ

A61K 31505
C07D40306

514253

Novel substituted-3-(4-phenyl-1-piperazinyl)alkyl quinazolin-2,4-(1H,3H)diones are described. These compounds are useful as antihypertensive agents.

46687874, May 26, 1987

Dec 20, 1985

6/811238

Victor T. Bandurco - Bridgewater NJ
Stanley C. Bell - Narberth PA
Robert Falotico - Belle Mead NJ
Charles F. Schwender - Califon NJ
Alfonso J. Tobia - Doylestown PA

Ortho Pharmaceutical Corporation - Raritan NJ

C07D23980

544286

Quinazolinone derivatives having an oxy substituent in the 5- and 6-positions are disclosed. The quinazolinone derivatives are useful as cardiovascular agents.

45567395, Dec 3, 1985

Jul 2, 1984

6/627139

Ramesh M. Kanojia - Somerville NJ
Victor T. Bandurco - Bridgewater NJ
Seymour D. Levine - North Brunswick NJ
Dennis M. Mulvey - New Hope PA
Alfonso J. Tobia - Doylestown PA

Ortho Pharmaceutical Corporation - Raritan NJ

C07C 8752

564443

A process for preparing 4-alkyl-2(1H)quinazolinone-1-alkanoic acid derivatives is described. The 4-alkyl-2(1H)quinazolinones are useful as cardiovascular agents.