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Alexei I Degterev

from Brookline, MA
Age ~52
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Also known as:
Alexi I Degterev, Degterev I Alexei, Alexe Degterev
Phone and address:
48 Regent Cir, Brookline, MA 02445
(617) 953-5641
Connected to:
Vadim Degtiarev, 57Maria Degtyareva, 40Jerry Deguair, 55Deborah L Deguara, 73Nancy L Deguara, 54Manabu Deguchi, 59Naomi Deguchi, 50Daniel E Degucz, 61Joanne M Degueldre, 72Connie L Deguerre, 66

Alexei Degterev Phones & Addresses

  • 48 Regent Cir, Brookline, MA 02445 (617) 953-5641
  • 136 Lake Shore Rd, Brighton, MA 02135
  • 186 Lake Shore Rd, Brighton, MA 02135
  • Boston, MA
  • East Weymouth, MA
  • 136 Lake Shore Rd APT 3, Brighton, MA 02135

Publications

Us Patents

Small Molecule Inhibitors Of Necrosis

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US Patent:
6756394, Jun 29, 2004
Filed:
Oct 13, 2000
Appl. No.:
09/688015
Inventors:
Junying Yuan - Newton MA
Alexei Degterev - Brighton MA
Timothy J. Mitchison - Brookline MA
Assignee:
President and Fellow of Harvard College - Cambridge MA
International Classification:
A61P 2528
US Classification:
514389
Abstract:
The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.

Small Molecules Used To Increase Cell Death

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US Patent:
7144905, Dec 5, 2006
Filed:
Mar 16, 2004
Appl. No.:
10/802902
Inventors:
Junying Yuan - Newton MA, US
Alexei Degterev - Brighton MA, US
Timothy J. Mitchison - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 31/426
C07D 277/04
US Classification:
514369, 548146, 548182, 548183, 514365
Abstract:
The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.

Small Molecule Inhibitors Of Necrosis

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US Patent:
7253201, Aug 7, 2007
Filed:
Jun 29, 2004
Appl. No.:
10/880377
Inventors:
Junying Yuan - Newton MA, US
Alexei Degterev - Brighton MA, US
Timothy J. Mitchison - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 31/416
US Classification:
514403
Abstract:
The invention features methods for decreasing necrosis. The invention also features methods for treating a subject with a condition in which necrosis occurs. The invention further features chemical compounds used to decrease necrosis.

Small Molecules Used To Increase Cell Death

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US Patent:
7390836, Jun 24, 2008
Filed:
Nov 30, 2006
Appl. No.:
11/606583
Inventors:
Junying Yuan - Newton MA, US
Alexei Degterev - Brighton MA, US
Timothy J. Mitchison - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 31/167
US Classification:
514617, 514622
Abstract:
The invention features methods for increasing cell death. The invention also features compounds used to increase cell death. The invention further features methods for identifying compounds that increase cell death.

Inhibitors Of Cellular Necrosis

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US Patent:
7491743, Feb 17, 2009
Filed:
Aug 30, 2004
Appl. No.:
10/930690
Inventors:
Gregory D. Cuny - Somerville MA, US
Junying Yuan - Newton MA, US
Prakash Jagtap - Beverly MA, US
Alexei Degterev - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 31/415
C07D 403/02
US Classification:
514397, 514398, 5483121
Abstract:
The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

Inhibitors Of Cellular Necrosis

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US Patent:
8143300, Mar 27, 2012
Filed:
Mar 18, 2008
Appl. No.:
12/077320
Inventors:
Gregory D. Cuny - Somerville MA, US
Prakash Jagtap - North Andover MA, US
Junying Yuan - Newton MA, US
Alexei Degterev - Brookline MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 31/415
C07D 401/00
US Classification:
514397, 514256, 544333, 548398
Abstract:
The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with cell death. Methods and compositions of the invention are particularly useful for treating neurological disorders associated with cellular necrosis.

Heterocyclic Inhibitors Of Necroptosis

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US Patent:
8278344, Oct 2, 2012
Filed:
Aug 20, 2010
Appl. No.:
12/859997
Inventors:
Gregory D. Cuny - Somerville MA, US
Xin Teng - Framingham MA, US
Junying Yuan - Newton MA, US
Alexei Degterev - Brookline MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
Tufts University - Boston MA
International Classification:
A61K 31/40
US Classification:
514423
Abstract:
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role.

Tricyclic Necrostatin Compounds

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US Patent:
8324262, Dec 4, 2012
Filed:
Dec 20, 2006
Appl. No.:
12/086792
Inventors:
Junying Yuan - Waban MA, US
Alexei Degterev - Brookline MA, US
Junichi Hitomi - Brookline MA, US
Gregory D. Cuny - Somerville MA, US
Prakash Jagtap - North Andover MA, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61K 31/416
A61K 31/4162
C07D 231/54
C07D 491/048
US Classification:
514403, 5483591, 514656, 514680
Abstract:
The present invention features compounds, pharmaceutical compositions, and methods for treating trauma, ischemia, stroke, degenerative diseases associated with cellular necrosis, and other conditions. Screening assays for identifying compounds useful for treating these conditions are also described.
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Alexei I Degterev from Brookline, MA, age ~52 Get Report