US Patent:
20120014993, Jan 19, 2012
Inventors:
James R. Walker - Austin TX, US
Alexandra Blinkova - Austin TX, US
Philip Tucker - Austin TX, US
International Classification:
A61K 39/08
A61P 37/00
G01N 33/554
C40B 30/04
C12N 1/20
A61K 35/74
US Classification:
4242471, 4352527, 424 9341, 435 732, 506 9
Abstract:
The present disclosure relates to spore surface display compositions comprising a spore having at least one nucleic acid sequence encoding for at least one polypeptide and operable to express the polypeptide on a surface of the spore. In some embodiments, the displayed polypeptide is displayed with a spore carrier protein. In some embodiments, the spore may be derived from a sp. such as . Spore display compositions of the disclosure may include vaccines, fusion proteins, drug delivery devices, systems for generating an antibody to an antigen/peptide expressed on a spore surface, an anticancer drug, an immobilized enzyme system, a system for serological reagent preparation, a contaminant removal system, a biocatalysis system, a screening platform, a nanotechnology platform, a bioanalytical sensor, a molecular electronic system and/or a signal processing system. Methods for making and using these compositions are described.