Alexander W Rhind

6849458, Feb 1, 2005

Mar 9, 2001

09/801676

Michael W. Pantoliano - Avondale PA, US
Roger F. Bone - Bridgewater NJ, US
Alexander W. Rhind - Libertyville IL, US
Francis R. Salemme - Yardley PA, US

G01N 3353

436 86, 436147, 436501, 436518, 435 71

The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e. g. , one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a predetermined profile.

20030203497, Oct 30, 2003

Apr 22, 2003

10/419973

Michael Pantoliano - Avondale PA, US
Roger Bone - Bridgewater NJ, US
Alexander Rhind - Libertyville IL, US
Francis Salemme - Yardley PA, US

G01N033/00

436/086000

The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.

20040185504, Sep 23, 2004

Apr 7, 2004

10/821274

Michael Pantoliano - Avondale PA, US
Roger Bone - Bridgewater NJ, US
Alexander Rhind - Libertyville IL, US
Francis Salemme - Yardley PA, US

C12Q001/68
G01N033/53
G06F019/00
G01N033/48
G01N033/50

435/007100, 702/019000

The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving means can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving means can be configured to receive spectral emission from the samples in a variety of ways, e.g., one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting means can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.

62682180, Jul 31, 2001

Dec 14, 1999

9/459997

Michael W. Pantoliano - Avondale PA
Roger F. Bone - Bridgewater NJ
Alexander W. Rhind - Libertyville IL
Francis R. Salemme - Yardley PA

3-Dimensional Pharmaceuticals, Inc. - Exton PA

G01N 2164

436 86

The present invention provides an assay apparatus for that includes a temperature adjusting device for simultaneously heating a plurality of samples, and a receiving device for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving device can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving device can be configured to receive spectral emission from the samples in a variety of ways, e. g. , one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting device can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.

6020141, Feb 1, 2000

May 9, 1997

8/853464

Michael W. Pantoliano - Avondale PA
Alexander W. Rhind - Libertyville IL
Francis R. Salemme - Yardley PA

3-Dimensional Pharmaceuticals, Inc. - Exton PA

G01N 3353
C12Q 100

435 71

The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change. The method comprises contacting the target molecule with one molecule of the multiplicity of different molecules in each of a multiplicity of containers, simultaneously heating the multiplicity of containers, measuring in each of the containers a physical change associated with the thermal denaturation of the target molecule resulting from the heating in each of the containers, generating a thermal denaturation curve for the target molecule as a function of temperature for each of the containers and determining a midpoint temperature (T. sub. m) therefrom, comparing the T. sub. m of each of the thermal denaturation curves with the T. sub.

63033224, Oct 16, 2001

Jan 5, 2000

9/478216

Michael W. Pantoliano - Avondale PA
Alexander W. Rhind - Libertyville IL
Francis R. Salemme - Yardley PA

3-Dimensional Pharmaceuticals, Inc. - Exton PA

G01N 3353
C12Q 168

435 71

The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change. The method comprises contacting the target molecule with one molecule of the multiplicity of different molecules in each of a multiplicity of containers, simultaneously heating the multiplicity of containers, measuring in each of the containers a physical change associated with the thermal denaturation of the target molecule resulting from the heating in each of the containers, generating a thermal denaturation curve for the target molecule as a function of temperature for each of the containers and determining a midpoint temperature (T. sub. m) therefrom, comparing the T. sub. m of each of the thermal denaturation curves with the T. sub.

62911910, Sep 18, 2001

Dec 2, 1999

9/452203

Michael W. Pantoliano - Avondale PA
Eugenio C. Petrella - Wayne PA
Alexander W. Rhind - Libertyville IL
Francis R. Salemme - Yardley PA
Barry A. Springer - Wilmington DE

3-Dimensional Pharmaceuticals, Inc. - Exton PA

G01N 3353
C12Q 168

435 71

The present invention is a method for ranking the affinity of each of a multiplicity of different molecules for a target molecule which is capable of denaturing due to a thermal change. The method comprises contacting the target molecule with one molecule of the multiplicity of different molecules in each of a multiplicity of containers, simultaneously heating the multiplicity of containers, measuring in each of the containers a physical change associated with the thermal denaturation of the target molecule resulting from the heating in each of the containers, generating a thermal denaturation curve for the target molecule as a function of temperature for each of the containers and determining a midpoint temperature (T. sub. m) therefrom, comparing the T. sub. m of each of the thermal denaturation curves with the T. sub.

60369205, Mar 14, 2000

May 9, 1997

8/853459

Michael W. Pantoliano - Avondale PA
Roger F. Bone - Bridgewater NJ
Alexander W. Rhind - Libertyville IL
Francis R. Salemme - Yardley PA

3-Dimensional Pharmaceuticals, Inc. - Exton PA

G01N 2164

422 67

The present invention provides an assay apparatus for that includes a temperature adjusting device for simultaneously heating a plurality of samples, and a receiving device for receiving spectral emission from the samples while the samples are being heated. In further aspects of the invention, the receiving device can be configured to receive fluorescent emission, ultraviolet light, and visible light. The receiving device can be configured to receive spectral emission from the samples in a variety of ways, e. g. , one sample at a time, simultaneously from more than one sample, or simultaneously from all of the samples. The temperature adjusting device can be configured with a temperature controller for changing temperature in accordance with a pre-determined profile.