US Patent:
20220289796, Sep 15, 2022
Inventors:
- Chapel Hill NC, US
Stephan T. Kudlacek - Katy TX, US
Aravinda De Silva - Chapel Hill NC, US
Alexander Payne - New York NY, US
Thanh Phan - Carrboro NC, US
Stefan Metz - Durham NC, US
International Classification:
C07K 14/005
A61K 39/12
A61P 31/14
Abstract:
The present invention provides compositions and methods of use comprising a stabilized recombinant E glycoprotein comprising a flavivirus E glycoprotein backbone, which comprises amino acid substitutions that stabilize the E glycoprotein in dimer conformation under physiological conditions.