Alexander Jackson Lovejoy

20230081899, Mar 16, 2023

Nov 3, 2022

18/052337

- Pleasanton CA, US
Alexander Lovejoy - Newark CA, US
Seyed Hamid Mirebrahim - Dublin CA, US
Amrita Pati - San Ramon CA, US

C12N 15/10

The present disclosure provides a kit for preparing a library of nucleic acids. The kit includes first and second oligonucleotide, each having a tail sequence, a common sequence, and at least one of a unique identifier sequence, and a variable length punctuation mark. The kit further includes a first primer having a first sample identifier sequence and a first priming sequence at a 3′ end of the first primer. The first priming sequence includes the tail sequence of the first oligonucleotide. The kit further includes a second primer having a second sample identifier sequence and a second priming sequence at a 3′ end of the second primer. The second priming sequence is complimentary to the second tail sequence of the second oligonucleotide.

20230083203, Mar 16, 2023

Oct 14, 2022

18/046565

- Pleasanton CA, US
Alexander Lovejoy - Newark CA, US
John Palma - Alamo CA, US
Ulrich-Peter Rohr - Loerrach, DE
Lijing Yao - Foster City CA, US
Stephanie Yaung - San Jose CA, US

C12Q 1/6886
G16B 20/20

The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising analysis of circulating tumor DNA from a patient's sample.

20200392483, Dec 17, 2020

Jun 22, 2020

16/907736

- Pleasanton CA, US
- Wilmington MA, US
Alexander Lovejoy - Newark CA, US
Bronwen Miller - Cape Town, ZA
Jo-Anne Elizabeth Penkler - Cape Town, ZA
Joseph Platzer - Oakland CA, US

C12N 15/10
C12Q 1/6874

The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. A first oligonucleotide is hybridized to a target nucleic acid in library of nucleic acids having first and second adapters. The hybridized first oligonucleotide is extended with a first polymerase, thereby producing a first primer extension complex including the target nucleic acid and the extended first oligonucleotide. The first primer extension complex is captured, enriched relative to the library of nucleic acids, and a second oligonucleotide is hybridized to the target nucleic acid. The hybridized second oligonucleotide is extended with a second polymerase, thereby producing a second primer extension complex including the target nucleic acid and the extended second oligonucleotide, and further liberating the extended first oligonucleotide from the first primer extension complex.

20200109397, Apr 9, 2020

Dec 19, 2019

16/721533

- Pleasanton CA, US
Alexander Lovejoy - Newark CA, US
Seyed Hamid Mirebrahim - Dublin CA, US
Amrita Pati - San Ramon CA, US

C12N 15/10

The present disclosure provides a kit for preparing a library of nucleic acids. The kit includes first and second oligonucleotide, each having a tail sequence, a common sequence, and at least one of a unique identifier sequence, and a variable length punctuation mark. The kit further includes a first primer having a first sample identifier sequence and a first priming sequence at a 3′ end of the first primer. The first priming sequence includes the tail sequence of the first oligonucleotide. The kit further includes a second primer having a second sample identifier sequence and a second priming sequence at a 3′ end of the second primer. The second priming sequence is complimentary to the second tail sequence of the second oligonucleotide.

20200032244, Jan 30, 2020

Aug 15, 2019

16/542127

- Pleasanton CA, US
- Wilmington MA, US
Alexander Lovejoy - Newark CA, US
Bronwen Miller - Cape Town, ZA
Jo-Anne Elizabeth Penkler - Cape Town, ZA
Joseph Platzer - Oakland CA, US
Martin Ranik - Santa Clara CA, US

C12N 15/10
C12Q 1/6813
C12Q 1/6876

The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. A first oligonucleotide is hybridized to a target nucleic acid in library of nucleic acids having first and second adapters. The hybridized first oligonucleotide is extended with a first polymerase, thereby producing a first primer extension complex including the target nucleic acid and the extended first oligonucleotide. The first primer extension complex is captured, enriched relative to the library of nucleic acids, and a second oligonucleotide is hybridized to the target nucleic acid. The hybridized second oligonucleotide is extended with a second polymerase, thereby producing a second primer extension complex including the target nucleic acid and the extended second oligonucleotide, and further liberating the extended first oligonucleotide from the first primer extension complex.