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Alexander N Lagadinos

from Melrose, MA
Age ~41
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Related to:
Barry G Lagadinos, 73Amanda L Gemme, 32Erin M Crowley, 56
Connected to:
Laurence C Lagae, 54Carmen Lagaipa, 59Andrea Lagala, 38Eileen D Lagala, 70Amanda L Lagamba, 33Joseph A Lagamba, 73Sharon K Lagamba, 62James V Lagamma, 109Andrew W Lagan, 39Lee A Lagan, 53

Alexander Lagadinos Phones & Addresses

  • Melrose, MA
  • 11 Overlook Ridge Dr APT 226, Revere, MA 02151
  • Pomona, CA
  • 17 Federal St, Worcester, MA 01608
  • 17 Federal St #706, Worcester, MA 01608
  • 13 Thankful Ln, Cotuit, MA 02635 (508) 428-4097
  • Centerville, MA
  • Florence, MA
  • Fitchburg, MA
  • Walpole, MA
  • Sandwich, MA
  • 13 Thankful Ln, Cotuit, MA 02635

Work

Company: University of massachusetts medical school 2005 Position: Doctoral graduate student

Education

Degree: Ph.D. School / High School: UMass Medical School 2005 to 2012 Specialities: Virology

Skills

Molecular Biology • Virology • Statistical Modeling • DNA • Genetics • Life Sciences • Cell Biology • Biotechnology • RNA • Perl Scripting • Python Scripting • Written & Oral Presentation Skills • Collaborative Problem Solving • Artistic Eye • Account Management • Science Journalism • Poster Presentations • Grant Writing • Editorial Consulting • Fluorescence Microscopy • Lifesciences

Awards

Immunology/Virology Training Grant, NIH ...

Interests

musical production and performance, outd...

Emails

l***[email protected]

Industries

Biotechnology

Resumes

Resumes

Alexander Lagadinos Photo 1

Graduate Student At University Of Massachusetts Medical School

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Position:
Doctoral Graduate Student at University of Massachusetts Medical School
Location:
Greater Boston Area
Industry:
Biotechnology
Work:
University of Massachusetts Medical School since 2005
Doctoral Graduate Student
Worcester Polytechnic Institute - Worcester, MA Nov 2006 - 2011
Assistant Lacrosse Coach
UMass Medical School - Dr. Celia Schiffer's Laboratory 2004 - 2005
Lab Technician
Education:
UMass Medical School 2005 - 2012
Ph.D., Virology Worcester Polytechnic Institute 2001 - 2005
B.S., Biology and Biotechnology Barnstable High School
Skills:
Molecular Biology
Virology
Statistical Modeling
DNA
Genetics
Life Sciences
Cell Biology
Biotechnology
RNA
Perl Scripting
Python Scripting
Written & Oral Presentation Skills
Collaborative Problem Solving
Artistic Eye
Account Management
Science Journalism
Poster Presentations
Grant Writing
Editorial Consulting
Fluorescence Microscopy
Lifesciences
Interests:
musical production and performance, outdoors, sports, exercise, mental and physical health, self awareness, scientific research, molecular biology, intellectual property, discovery, invention, artistic endeavor, creativity, beautiful things...
Honor & Awards:
Immunology/Virology Training Grant, NIH AIO7349-18

Publications

Us Patents

Modulation Of Human Cytomegalovirus Replication By Micro-Rna 132 (Mir132), Micro-Rna 145 (Mir145) And Micro-Rna 212 (Mir212)

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US Patent:
20120178791, Jul 12, 2012
Filed:
Sep 7, 2011
Appl. No.:
13/227117
Inventors:
Timothy F. KOWALIK - Princeton MA, US
Mariluz RODRIGUEZ-GONZALEZ - Worcester MA, US
Alexander LAGADINOS - Worcester MA, US
Assignee:
UNIVERSITY OF MASSACHUSETTS - Boston MA
International Classification:
A61K 31/7088
A61P 31/22
C12Q 1/70
C12N 7/06
A61K 31/713
US Classification:
514 44 A, 435238, 435 5
Abstract:
The present invention related to miR145, miR132, miR212, and the genes or gene products regulated by these miRNAs. miR145 is downregulated in cells infected with HCMV. This downregulation modulates expression of miR145 target genes, including IRS-I. Transfection of cells with a miR145 agent, such as a miR145 mimetic, reduces HCMV replication and protein expression. miR132 and miR212 are upregulated in cells infected with HCMV. This upregulation modulates expression of miR132 and miR212 target genes, including MeCP2 and RICS. Transfection of cells with a miR132 and/or a miR212 antagonist reduces HCMV replication and protein expression. Accordingly, the invention provides methods of attenuating HCMV replication by modulating, for example, miR145, miR132, and/or miR212, and targets thereof. Also provided are methods of detecting an HCMV infection, and compositions and kits useful for attenuating HCMV replication.

Modulation Of Human Cytomegalovirus Replication By Micro-Rna 132 (Mir132), Micro-Rna 145 (Mir145) And Micro-Rna 212 (Mir212)

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US Patent:
20170101640, Apr 13, 2017
Filed:
Dec 19, 2016
Appl. No.:
15/383600
Inventors:
- Boston MA, US
Mariluz Rodriguez-Gonzalez - Worcester MA, US
Alexander Lagadinos - Worcester MA, US
International Classification:
C12N 15/113
G01N 33/569
C12Q 1/70
A61K 31/7105
A61K 45/06
Abstract:
The present invention relates to miR145, miR132, miR212, and the genes or gene products regulated by these miRNAs. miR145 is downregulated in cells infected with HCMV. This downregulation modulates expression of miR145 target genes, including IRS-1. Transfection of cells with a miR145 agent, such as a miR145 mimetic, reduces HCMV replication and protein expression. miR132 and miR212 are upregulated in cells infected with HCMV. This upregulation modulates expression of miR132 and miR212 target genes, including MeCP2 and RICS. Transfection of cells with a miR132 and/or a miR212 antagonist reduces HCMV replication and protein expression. Accordingly, the invention provides methods of attenuating HCMV replication by modulating, for example, miR145, miR132, and/or miR212, and targets thereof. Also provided are methods of detecting an HCMV infection, and compositions and kits useful for attenuating HCMV replication.

Modulation Of Human Cytomegalovirus Replication By Micro-Rna 132 (Mir132), Micro-Rna 145 (Mir145) And Micro-Rna 212 (Mir212)

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US Patent:
20150259689, Sep 17, 2015
Filed:
Dec 8, 2014
Appl. No.:
14/563512
Inventors:
- Boston MA, US
Mariluz Rodriguez-Gonzalez - Worcester MA, US
Alexander Lagadinos - Worcester MA, US
International Classification:
C12N 15/113
C12Q 1/70
A61K 45/06
A61K 31/7105
Abstract:
The present invention related to miR145, miR132, miR212, and the genes or gene products regulated by these miRNAs. miR145 is downregulated in cells infected with HCMV. This downregulation modulates expression of miR145 target genes, including IRS-1. Transfection of cells with a miR145 agent, such as a miR145 mimetic, reduces HCMV replication and protein expression. miR132 and miR212 are upregulated in cells infected with HCMV. This upregulation modulates expression of miR132 and miR212 target genes, including MeCP2 and RICS. Transfection of cells with a miR132 and/or a miR212 antagonist reduces HCMV replication and protein expression. Accordingly, the invention provides methods of attenuating HCMV replication by modulating, for example, miR145, miR132, and/or miR212, and targets thereof. Also provided are methods of detecting an HCMV infection, and compositions and kits useful for attenuating HCMV replication.
Control profile
Alexander N Lagadinos from Melrose, MA, age ~41 Get Report