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Alexander A Astrakhan

from Seattle, WA
Age ~44
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Also known as:
Alexandr Astrakhan, Alex Astrakhan
Related to:
David AbbottBenjamin J Abbott, 51Jannette Paulu, 74Hillary Lyons, 54
Connected to:
Boris K Astrakhan, 78Vadim G Astrakhan, 48Andres A Astralaga, 53Marcela Astralaga, 51Antonio A Astran, 64Javier R Astran, 44George R Astrauckas, 75Joe Astrauckas, 80Christopher J Astrauskas, 53Jurgis Astrauskas, 62

Alexander Astrakhan Phones & Addresses

  • Seattle, WA
  • Cary, NC

Work

Company: Bluebird bio Jul 2020 Position: Director

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Washington 2005 to 2010 Specialities: Immunology

Skills

Flow Cytometry • Cell Biology • Molecular Biology • Gene Therapy • Immunology • Tissue Culture • Lifesciences • Assay Development • Animal Models • Genetic Engineering • Grant Writing • Scientific Writing • Stem Cells

Languages

English • Russian

Industries

Biotechnology

Resumes

Resumes

Alexander Astrakhan Photo 1

Director

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Location:
1616 Eastlake Ave east, Seattle, WA 98102
Industry:
Biotechnology
Work:
Bluebird Bio
Director
Pregenen Sep 2011 - Jun 2014
Director, Preclinical Development
University of Washington Jan 2011 - Aug 2011
Postdoctoral Fellow
Seattle Children's Sep 2002 - Jun 2005
Research Scientist
Seattle Children's 2003 - 2005
Manager, Flow Cytometry Core
Education:
University of Washington 2005 - 2010
Doctorates, Doctor of Philosophy, Immunology University of North Carolina at Chapel Hill 1998 - 2002
Bachelors, Bachelor of Science, Biology
Skills:
Flow Cytometry
Cell Biology
Molecular Biology
Gene Therapy
Immunology
Tissue Culture
Lifesciences
Assay Development
Animal Models
Genetic Engineering
Grant Writing
Scientific Writing
Stem Cells
Languages:
English
Russian

Publications

Us Patents

Dimerizing Agent Regulated Immunoreceptor Complexes

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US Patent:
20230031838, Feb 2, 2023
Filed:
Sep 30, 2020
Appl. No.:
17/764365
Inventors:
- Cambridge MA, US
ALEXANDER ASTRAKHAN - SEATTLE WA, US
WAI-HANG LEUNG - SEATTLE WA, US
Assignee:
2seventy bio, Inc. - Cambridge MA
International Classification:
C12N 9/90
C07K 14/725
C07K 14/73
C07K 14/705
A61K 35/17
C07K 16/28
Abstract:
The present disclosure provides adoptive T cell therapies that have improved DARIC architectures for targeting tumor antigens and recruiting TCR signaling complexes for treating, preventing, or ameliorating at least one symptom of a cancer, infectious disease, autoimmune disease, inflammatory disease, and immunodeficiency, or condition associated therewith.

Multipartite Signaling Proteins And Uses Thereof

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US Patent:
20200071399, Mar 5, 2020
Filed:
Aug 14, 2019
Appl. No.:
16/540673
Inventors:
- Cambridge MA, US
Alexander Astrakhan - Seattle WA, US
Michael Certo - Medford MA, US
Assignee:
bluebird bio, Inc. - Cambridge MA
International Classification:
C07K 16/28
C07K 14/705
C07K 14/725
C07K 14/73
C07K 14/735
C12N 9/06
C12N 9/16
A61K 35/17
A61K 39/00
A61K 45/06
C07K 16/40
C12N 9/12
C12N 9/90
C12N 15/85
Abstract:
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Multipartite Signaling Proteins And Uses Thereof

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US Patent:
20200071401, Mar 5, 2020
Filed:
Sep 17, 2019
Appl. No.:
16/573254
Inventors:
- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Michael CERTO - Medford MA, US
Assignee:
bluebird bio, Inc. - Cambridge MA
International Classification:
C07K 16/28
C12N 15/85
C07K 14/705
C12N 9/90
C12N 9/12
C07K 16/40
A61K 45/06
A61K 39/00
A61K 35/17
C12N 9/16
C12N 9/06
C07K 14/735
C07K 14/73
C07K 14/725
Abstract:
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Donor Repair Templates Multiplex Genome Editing

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US Patent:
20190390189, Dec 26, 2019
Filed:
Feb 15, 2018
Appl. No.:
16/485345
Inventors:
- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Assignee:
bluebird bio, Inc. - Cambridge MA
International Classification:
C12N 15/10
C07K 14/725
C12N 15/86
A61K 35/17
C12N 9/22
C07K 14/705
C07K 16/28
C12N 15/66
Abstract:
The present disclosure provides improved multiplex genome editing compositions and methods. The disclosure further provides genome edited cells for the prevention, treatment, or amelioration of at least one symptom of a hemoglobinopathy, a cancer, an infectious disease, an autoimmune disease, an inflammatory disease, or an immunodeficiency.

Multipartite Signaling Proteins And Uses Thereof

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US Patent:
20190112372, Apr 18, 2019
Filed:
Dec 13, 2018
Appl. No.:
16/219640
Inventors:
- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Michael CERTO - Medford MA, US
Assignee:
bluebird bio, Inc. - Cambridge MA
International Classification:
C07K 16/28
C07K 14/705
C12N 9/06
C12N 9/16
C12N 15/85
C07K 16/40
A61K 39/00
A61K 45/06
C12N 9/12
C12N 9/90
A61K 35/17
C07K 14/73
C07K 14/725
C07K 14/735
Abstract:
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Multipartite Signaling Proteins And Uses Thereof

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US Patent:
20160311901, Oct 27, 2016
Filed:
Jul 23, 2014
Appl. No.:
14/908734
Inventors:
- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Michael CERTO - Brookline MA, US
International Classification:
C07K 16/28
C12N 9/12
C12N 15/85
C12N 9/90
C07K 14/705
C07K 14/725
Abstract:
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.

Multipartite Signaling Proteins And Uses Thereof

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US Patent:
20150266973, Sep 24, 2015
Filed:
Jan 28, 2015
Appl. No.:
14/608098
Inventors:
- Cambridge MA, US
Alexander ASTRAKHAN - Seattle WA, US
Michael CERTO - Brookline MA, US
International Classification:
C07K 16/40
C12N 9/12
A61K 39/00
A61K 45/06
C07K 16/28
C07K 14/705
C12N 9/90
A61K 35/17
Abstract:
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
Control profile
Alexander A Astrakhan from Seattle, WA, age ~44 Get Report