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Aldo Algieri Phones & Addresses

  • 1100 Shallow Brook Ter, Webster, NY 14580 (860) 663-2094
  • 166 Bar Gate Trl, Killingworth, CT 06419 (860) 663-2094
  • 66 Bar Gate Trl, Killingworth, CT 06419 (203) 663-2094 (860) 663-2094
  • Fayetteville, NY

Publications

Us Patents

Chemical Intermediates And Process

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US Patent:
49279688, May 22, 1990
Filed:
Apr 11, 1988
Appl. No.:
7/174444
Inventors:
Aldo A. Algieri - Killingworth CT
Robert F. Farney - Evansville IN
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07C 9306
US Classification:
549451
Abstract:
The present invention relates to novel intermediates of the formula ##STR1## wherein R. sup. 1 is hydrogen or lower alkyl and R is ##STR2## --CH. sub. 2 OH or --CH. sub. 2 X in which X is a conventional leaving group and Y is lower alkyl and the use thereof in a process for the preparation of certain histamine H. sub. 2 -antagonists.

Chemical Compounds

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US Patent:
43806384, Apr 19, 1983
Filed:
Jun 23, 1981
Appl. No.:
6/276602
Inventors:
Ronnie R. Crenshaw - Dewitt NY
Aldo A. Algieri - Fayetteville NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D28510
US Classification:
548135
Abstract:
Histamine H. sub. 2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R. sup. 1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

3,4-Disubstituted-1,2,5-Thiadiazole-1-Oxide Compounds

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US Patent:
43742483, Feb 15, 1983
Filed:
Jun 23, 1981
Appl. No.:
6/276586
Inventors:
Ronnie R. Crenshaw - Dewitt NY
Aldo A. Algieri - Fayetteville NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D28510
US Classification:
548135
Abstract:
Histamine H. sub. 2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R. sup. 1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anit-ulcer agents. Intermediates and processes for their preparation are disclosed.

Ethanediimidamide Intermediates

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US Patent:
45957584, Jun 17, 1986
Filed:
Dec 3, 1984
Appl. No.:
6/677614
Inventors:
Ronnie R. Crenshaw - Dewitt NY
Aldo A. Algieri - Fayetteville NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D40912
US Classification:
546212
Abstract:
Histamine H. sub. 2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R. sup. 1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula ##STR2##.

Thiazole Derivatives

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US Patent:
42005787, Apr 29, 1980
Filed:
Dec 18, 1978
Appl. No.:
5/970517
Inventors:
Aldo A. Algieri - Fayetteville NY
Ronnie R. Crenshaw - Dewitt NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D27720
US Classification:
548193
Abstract:
Compounds of the formula ##STR1## wherein R. sup. 1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R. sup. 2 and R. sup. 3 each are independently hydrogen, (lower)alkyl, guanidino or --(CH. sub. 2). sub. p NR. sup. 4 R. sup. 5 ; R. sup. 4 and R. sup. 5 each are independently hydrogen, (lower)alkyl or phenyl; n is 2 or 3; p is 1, 2 or 3; X is NR. sup. 6 or CHR. sup. 6 ; R. sup. 6 is cyano, nitro, SO. sub. 2 Ar or SO. sub. 2 (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.

1-Amino-2-[3-(3-Piperidinomethylphenoxy)Propylamino]Cyclobutene-3,4-Dione

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US Patent:
43907016, Jun 28, 1983
Filed:
May 18, 1981
Appl. No.:
6/264533
Inventors:
Aldo A. Algieri - Fayetteville NY
Ronnie R. Crenshaw - Dewitt NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D29512
US Classification:
546235
Abstract:
Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones are potent histamine H. sub. 2 -antagonists useful in the treatment of peptic ulcers.

Substituted 1,2,5-Thiadiazole Derivatives

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US Patent:
43806392, Apr 19, 1983
Filed:
Jun 23, 1981
Appl. No.:
6/276606
Inventors:
Ronnie R. Crenshaw - Dewitt NY
Aldo A. Algieri - Fayetteville NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D28510
US Classification:
548135
Abstract:
Histamine H. sub. 2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R. sup. 1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2; n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.

Imidazolylalkylthioalkylamino-Ethylene Derivatives

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US Patent:
42007607, Apr 29, 1980
Filed:
Sep 26, 1978
Appl. No.:
5/945966
Inventors:
Aldo A. Algieri - Fayetteville NY
Ronnie R. Crenshaw - Dewitt NY
Assignee:
Bristol-Myers Company - New York NY
International Classification:
C07D23364
US Classification:
548342
Abstract:
Compounds of the formula ##STR1## wherein R. sup. 1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R. sup. 2 is hydrogen, (lower)alkyl, halogen or hydroxymethyl; m is 1 or 2, and n is 2 or 3, provided that the sum of m and n is 3 or 4; X and Y each are independently hydrogen, nitro, cyano, --SO. sub. 2 Ar or --COR. sup. 3, provided that X and Y are not both hydrogen; R. sup. 3 is (lower)alkyl, Ar, (lower)alkoxy, amino or (lower)-alkylamino; and Ar is an optionally substituted phenyl group; and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents. Processes for their preparation and novel intermediates are also disclosed.
Aldo A Algieri from Webster, NY, age ~78 Get Report