Alan E Moormann

6586474, Jul 1, 2003

Mar 23, 2001

09/816575

Ronald Keith Webber - St. Charles MO
Richard C. Durley - Chesterfield MO
Alok K. Awasthi - Skokie IL
Arija A. Bergmanis - Des Plaines IL
Kam F. Fok - St. Louis MO
Scott S. Ganser - Chicago IL
Timothy J. Hagen - Gurne IL
E. Ann Hallinan - Evanston IL
Brian S. Hickory - Wildwood MO
Pamela T. Manning - Labadie MO
Michael Mao - Chesterfield MO
Alan E. Moormann - Weldon Spring MO
Barnett S. Pitzele - Skokie IL
Michelle A. Promo - Chesterfield MO
Richard R. Schartman - Evanston IL
Jeffrey A. Scholten - Chesterfield MO
Jeffrey S. Snyder - Manchester MO
Mihaly V. Toth - St. Louis MO
Mahima Trivedi - Glenview IL
Sofya Tsymbalov - Skokie IL
Foe Siong Tjoeng - Ballwin MO

Pharmacia Corporation - St. Louis MO

A61K 31195

514562, 560153, 562557

The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.

6969715, Nov 29, 2005

Oct 3, 2002

10/263637

Michael S. South - St. Louis MO, US
Ronald K. Webber - St. Charles MO, US
Horng-Chih Huang - Chesterfield MO, US
Mihaly V. Toth - St. Louis MO, US
Alan E. Moormann - Weldon Spring MO, US
Jeffery S. Snyder - Manchester MO, US
Jeffrey A. Scholten - Chesterfield MO, US
Danny J. Garland - Ballwin MO, US
Melvin L. Rueppel - St. Louis MO, US
William L. Neumann - St. Louis MO, US
Scott Long - Ballwin MO, US
Wei Huang - Wildwood MO, US
John Trujillo - St. Peters MO, US
John J. Parlow - Arnold MO, US
Darin E. Jones - Ballwin MO, US
Brenda Case - St. Louis MO, US
Michael J. Hayes - St. Louis MO, US

Pharmacia Corporation - St. Louis MO

C07D253/06
A61K031/53
A61P009/10

514242, 544182

The present invention relates to compounds, and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.

20040082585, Apr 29, 2004

Oct 3, 2002

10/263418

Michael South - St. Louis MO, US
Ronald Webber - St. Charles MO, US
Horng-Chih Huang - Chesterfield MO, US
Mihaly Toth - St. Louis MO, US
Alan Moormann - Weldon Spring MO, US
Jeffery Snyder - Manchester MO, US
Jeffrey Scholten - Chesterfield MO, US
Danny Garland - Ballwin MO, US
Melvin Rueppel - St. Louis MO, US
William Neumann - St. Louis MO, US
Scott Long - Ballwin MO, US
Wei Huang - Wildwood MO, US
John Trujillo - St. Peters MO, US
John Parlow - Arnold MO, US
Darin Jones - Ballwin MO, US
Brenda Case - St. Louis MO, US
Michael Hayes - St. Louis MO, US
Qingping Zeng - Thousand Oaks CA, US

Pharmacia Corporation

A61K031/497
A61K031/513
C07D213/70
C07C050/12

514/252100, 514/269000, 514/460000, 514/690000, 544/298000, 514/408000, 546/290000, 514/345000, 549/273000, 552/296000

The present invention relates to prodrug compounds, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.

52349217, Aug 10, 1993

Jun 10, 1992

7/896244

Daniel L. Flynn - Mundelein IL
Alan E. Moormann - Skokie IL
Roger Nosal - Buffalo Grove IL

G. D. Searle & Co. - Chicago IL

A61K 31435
A61K 31395
C07D47118
C07D48718

514214

The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT. sub. 3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT. sub. 3 receptors is beneficial. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbancies (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.

53547578, Oct 11, 1994

Dec 15, 1992

7/991028

Daniel L. Flynn - Mundelein IL
Alan E. Moormann - Skokie IL

G. D. Searle & Co. - Chicago IL

A61K 31445
C07D22122

514290

This invention relates to compounds of the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein Z is selected from the group consisting of ##STR2## R. sub. 1 is alkoxy of one to six carbon atoms; R. sub. 2, R. sub. 3, R. sub. 4 and R. sub. 5 are the same or different and are selected from the group consisting of hydrogen, halogen, CF. sub. 3, hydroxy, alkoxy of one to six carbon atoms, acyl of two to seven carbon atoms, amino, amino substituted by one or two alkyl groups of one to six carbon atoms, C. sub. 2 -C. sub. 7 acylamino, aminocarbonyl, aminosulfone optionally substituted by one or two alkyl groups of one to six carbon atoms, C. sub. 1 -C. sub. 6 alkylsulfone and nitro; n is 0, 1 or 2; m is 0 or 1; X is O or NR. sub. 7 ; and R. sub. 7 is hydrogen or alkyl of 1 to 6 carbon atoms.

52800288, Jan 18, 1994

Jun 24, 1992

7/903835

Daniel L. Flynn - Mundelein IL
Alan E. Moormann - Skokie IL

G. D. Searle & Co. - Chicago IL

C07D45100
C07D47100
A61K 3141
A61K 31435

514294

This invention relates to compounds useful in treating HT. sub. 4 and/or HT. sub. 3 mediated conditions of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R. sub. 1 and R. sub. 2 are independently selected from the group consisting of hydrogen, alkoxy, halogen, amino, monoalkylamino, dialkylamino, acylamino and alkylsulfonylamino; R. sub. 3 is selected from the group consisting of H, alkyl and cycloalkyl; X is NH or O; Z is selected from the group consisting of ##STR2## n and r are independently 1 or 2; p is 0 or 1; pharmaceutical compositions containing the compounds and a method for treating serotonin mediated condition with the compositions which act as 5-HT. sub. 4 agonists or antagonists and/or 5-HT. sub. 3 antagonists.

43407307, Jul 20, 1982

Jan 30, 1981

6/229824

Richard E. L. Henderson - Evanston IL
Nancy J. Malek - Skokie IL
Alan E. Moormann - Skokie IL
Barnett S. Pitzele - Skokie IL

G. D. Searle & Co. - Skokie IL

C07H 1916

536 26

Novel N. sup. 6 -adenosines according to formula I are disclosed. These novel compounds are useful as antihypertensive agents.

46877754, Aug 18, 1987

Jul 17, 1986

6/887842

Gilbert W. Adelstein - Evanston IL
Alan E. Moormann - Skokie IL
Stella S. T. Yu - Morton Grove IL

G. D. Searle & Co. - Chicago IL

A61K 31435
C07D47104

514300

This invention relates to 2-[(imidazo[1,2-a]pyridinylmethyl)-sulfinyl]-1H-benzimidazoles that are useful in the treatment and prevention of ulcers.