Resumes
Resumes
Alain Luxembourg Phones & Addresses
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440 S Broad St UNIT 1203, Philadelphia, PA 19146
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250 S 13Th St, Philadelphia, PA 19107 (267) 687-2814
s
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250 S 13Th St APT 10D, Philadelphia, PA 19107 (267) 687-2814
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8200 Avenel Blvd, North Wales, PA 19454 (215) 699-3436
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3718 Yosemite St, Pacific Beach, CA 92109 (858) 272-7392
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San Diego, CA
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8141 El Paseo Grande, La Jolla, CA 92037 (858) 456-9064
Publications
Us Patents
Antigen Presenting System And Methods For Activation Of T-Cells
View pageUS Patent:
6828150, Dec 7, 2004
Filed:
Oct 8, 2002
Appl. No.:
10/266463
Inventors:
Zeling Cai - San Diego CA
Jonathan Sprent - Leucadia CA
Anders Brunmark - San Diego CA
Michael Jackson - Del Mar CA
Per A. Peterson - Rancho Santa Fe CA
Alain Luxembourg - La Jolla CA
Didier J. Leturcq - San Diego CA
Ann M. Moriarty - Poway CA
Jonathan Sprent - Leucadia CA
Anders Brunmark - San Diego CA
Michael Jackson - Del Mar CA
Per A. Peterson - Rancho Santa Fe CA
Alain Luxembourg - La Jolla CA
Didier J. Leturcq - San Diego CA
Ann M. Moriarty - Poway CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C12N 500
US Classification:
435377, 435348, 435325, 435455, 435383, 530350
Abstract:
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8 T-cells to produce cytokines and become cytotoxic.
Purification Of Antigen-Specific T Cells
View pageUS Patent:
20040137617, Jul 15, 2004
Filed:
Feb 23, 2004
Appl. No.:
10/785472
Inventors:
Alain Luxembourg - La Jolla CA, US
Michael Jackson - Del Mar CA, US
Per Peterson - Sante Fe CA, US
Michael Jackson - Del Mar CA, US
Per Peterson - Sante Fe CA, US
International Classification:
A61K039/395
C12N005/08
C12N005/08
US Classification:
435/372000, 424/140100
Abstract:
A new method to capture, purify and expand antigen-specific T lymphocytes has been developed using magnetic beads coated with recombinant MHC class I molecules. This method was optimized using homogenous populations of naive T cells purified from mice transgenic for the 2C T cell receptor (TCR). These T cells were captured on beads coated with MHC class I molecules and the relevant antigenic peptides. MHC and peptide specificity was confirmed by the usage of irrelevant MHC peptide combinations. An enrichment of 800 to 1600 fold was measured, using 2C T cells mixed with irrelevant T cells, starting from a 2C T cell frequency of 1/3000. The same approach was used to purify antigen-specific CD8T cells from total CD8T cells from naive mice. The recovered cells could be expanded and specifically kill target cells in vitro; they had a significant effect in vivo as well. We expect this procedure to be suitable to purify and expand in vitro tumor- and virus-specific killer T cells for use in cell therapy.
Antigen Presenting System And Methods For Activation Of T-Cells
View pageUS Patent:
20050152916, Jul 14, 2005
Filed:
Dec 7, 2004
Appl. No.:
11/005750
Inventors:
Zeling Cai - San Diego CA, US
Jonathan Sprent - Leucadia CA, US
Anders Brunmark - San Diego CA, US
Michael Jackson - Del Mar CA, US
Per Peterson - Rancho Santa Fe CA, US
Alain Luxembourg - La Jolla CA, US
Didier Leturcq - San Diego CA, US
Ann Moriarty - Poway CA, US
Jonathan Sprent - Leucadia CA, US
Anders Brunmark - San Diego CA, US
Michael Jackson - Del Mar CA, US
Per Peterson - Rancho Santa Fe CA, US
Alain Luxembourg - La Jolla CA, US
Didier Leturcq - San Diego CA, US
Ann Moriarty - Poway CA, US
International Classification:
A61K039/00
C07K014/74
C07K014/74
US Classification:
424185100, 530350000
Abstract:
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8 T-cells to produce cytokines and become cytotoxic.
Purification Of Antigen-Specific T Cells
View pageUS Patent:
20060134125, Jun 22, 2006
Filed:
Sep 6, 2005
Appl. No.:
11/219967
Inventors:
Alain Luxembourg - La Jolla CA, US
Michael Jackson - Del Mar CA, US
Per Peterson - Sante Fe CA, US
Michael Jackson - Del Mar CA, US
Per Peterson - Sante Fe CA, US
Assignee:
Ortho Pharmaceutical Corporation - Raritan NJ
International Classification:
A61K 39/00
US Classification:
424184100
Abstract:
A new method to capture, purify and expand antigen-specific T lymphocytes has been developed using magnetic beads coated with recombinant MHC class I molecules. This method was optimized using homogenous populations of naive T cells purified from mice transgenic for the 2C T cell receptor (TCR). These T cells were captured on beads coated with MHC class I molecules and the relevant antigenic peptides. MHC and peptide specificity was confirmed by the usage of irrelevant MHC peptide combinations. An enrichment of 800 to 1600 fold was measured, using 2C T cells mixed with irrelevant T cells, starting from a 2C T cell frequency of 1/3000. The same approach was used to purify antigen-specific CD8 T cells from total CD8 T cells from naive mice. The recovered cells could be expanded and specifically kill target cells in vitro; they had a significant effect in vivo as well. We expect this procedure to be suitable to purify and expand in vitro tumor- and virus-specific killer T cells for use in cell therapy.
Synthetic Antigen Presenting Matrix
View pageUS Patent:
6461867, Oct 8, 2002
Filed:
Sep 8, 1997
Appl. No.:
08/913612
Inventors:
Zeling Cai - San Diego CA
Jonathan Sprent - Leucadia CA
Anders Brunmark - San Diego CA
Michael Jackson - Del Mar CA
Per A. Peterson - Rancho Santa Fe CA
Alain Luxembourg - La Jolla CA
Didier J. Leturcq - San Diego CA
Ann M. Moriarty - Poway CA
Jonathan Sprent - Leucadia CA
Anders Brunmark - San Diego CA
Michael Jackson - Del Mar CA
Per A. Peterson - Rancho Santa Fe CA
Alain Luxembourg - La Jolla CA
Didier J. Leturcq - San Diego CA
Ann M. Moriarty - Poway CA
Assignee:
The Scripps Research Institute - La Jolla CA
International Classification:
C12N 506
US Classification:
435348, 435325, 435455, 530350
Abstract:
Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a synthetic antigen presenting matrix for activating T lymphocytes to a specific peptide is described.