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Aftabul Haque

from Belmont, MA
Age ~51

Aftabul Haque Phones & Addresses

  • 9 Agassiz Ave, Belmont, MA 02478 (617) 484-1392
  • Cold Spring Harbor, NY
  • South Setauket, NY
  • Stony Brook, NY
  • 2601 SE Southeast Loop 323, Tyler, TX 75701 (903) 593-4178
  • Medford, MA

Publications

Us Patents

Ptp1B Inhibitors

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US Patent:
20130029366, Jan 31, 2013
Filed:
Apr 27, 2010
Appl. No.:
13/266430
Inventors:
Nicholas Tonks - Stony Brook NY, US
Aftabul Haque - Stony Brook NY, US
Assignee:
Cold Spring Harbor Laboratory - Cold Spring Harbor NY
International Classification:
C12N 9/96
C12Q 1/42
C40B 30/04
C07K 16/40
C07K 16/46
US Classification:
435 21, 5303891, 5303873, 506 9, 435188
Abstract:
Described herein are agents, including antibodies, antibody fragments, polypeptides and organic small molecules, that bind reversibly inactive PTP1B (designated herein in the alternative as PTP1B-SN or PTP1B-OX) and stabilize it (stabilize PTP1B-OX) in such a manner that they inhibit reactivation of reversibly oxidized, inactive PTP1B by reduction (by reducing agent) and have no substantial direct inhibitory effect on phosphatase activity/PTP1B activity (for example, as detectable in assays in vitro).
Aftabul Haque from Belmont, MA, age ~51 Get Report