US Patent:
20130029366, Jan 31, 2013
Inventors:
Nicholas Tonks - Stony Brook NY, US
Aftabul Haque - Stony Brook NY, US
Assignee:
Cold Spring Harbor Laboratory - Cold Spring Harbor NY
International Classification:
C12N 9/96
C12Q 1/42
C40B 30/04
C07K 16/40
C07K 16/46
US Classification:
435 21, 5303891, 5303873, 506 9, 435188
Abstract:
Described herein are agents, including antibodies, antibody fragments, polypeptides and organic small molecules, that bind reversibly inactive PTP1B (designated herein in the alternative as PTP1B-SN or PTP1B-OX) and stabilize it (stabilize PTP1B-OX) in such a manner that they inhibit reactivation of reversibly oxidized, inactive PTP1B by reduction (by reducing agent) and have no substantial direct inhibitory effect on phosphatase activity/PTP1B activity (for example, as detectable in assays in vitro).