Adolf K Leshchiner

47134488, Dec 15, 1987

Mar 12, 1985

6/710929

Endre A. Balazs - Ft. Lee NJ
Adolf Leshchiner - Fairview NJ
Adelya Leshchiner - Fairview NJ
Philip Band - Brooklyn NY

Biomatrix, Inc. - Ridgefield NJ

C08B 3708
C08F 800
C12P 1904
C12R 146

536 551

Disclosed is hylan, a chemically modified hyaluronic acid preparation characterized by the presence of small amounts (0. 005-0. 05% by weight) of aldehyde cross-linking groups covalently bonded to the hyaluronic acid molecular chains. Also disclosed is a method of obtaining hylan comprising treating hyaluronic acid in situ in animal tissues containing same with a treatment mixture including a reagent (typically an aldehyde) which is reactive towards hyaluronic acid and the proteins contained in the animal tissue.

47957417, Jan 3, 1989

May 6, 1987

7/047419

Adolf Leshchiner - Fairview NJ
Nancy E. Larsen - Southfield NY
Endre A. Balazs - Ft. Lee NJ
Sadek K. Hilal - Englewood Cliffs NJ

Biomatrix, Inc. - Ridgefield NJ

C08F 800
C08G 7908

514 21

Percutaneous emboli are formed for therapeutic and/or corrective reasons by using a composition which includes crosslinked gells of hyaluronic acid (HA), hylan (HY) or mixed crosslinked gels of HA or HY with other materials, thrombin and cationic substances containing quaternary ammonium groups. Other optional materials include fillers and radio-opaque substances.

51283263, Jul 7, 1992

Jul 23, 1990

7/559413

Endre A. Balazs - Ft. Lee NJ
Adolf Leshchiner - Fairview NJ
Nancy E. Larsen - Ridgefield Park NJ

Biomatrix, Inc. - Ridgefield NJ

A61K 31715
A61K 970
A61F 1300

514 54

Disclosed are drug delivery systems based on a polymeric component which is soluble or insoluble (cross-linked) hyaluronan or hyaluronan copolymerized with another hydrophilic polymer or hylan and one or more substances having biological or pharmacological activity and methods of preparing same.

52665631, Nov 30, 1993

Jan 11, 1990

7/464583

Endre A. Balazs - Ft. Lee NJ
Adolf Leshchiner - Fairview NJ

Biomatrix, Inc. - Ridgefield NJ

A61K 715
A61K 748
A61K 3170

514 42

Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic acid salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.

46056912, Aug 12, 1986

Jul 18, 1985

6/755976

Endre A. Balazs - Riverdale NY
Adolf Leshchiner - Fairview NJ

Biomatrix, Inc. - Ridgefield NJ

C08B 3708

524 27

Disclosed are cross-linked gels of hyaluronic acid, alone or mixed with other hydrophilic polymers and containing various substances or covalently bonded low molecular weight substances and processes for preparing them. These products are useful in numerous applications including cosmetic formulations and as drug delivery systems.

49137433, Apr 3, 1990

May 25, 1988

7/198312

George L. Brode - Bridgewater NJ
Philip A. Band - Brooklyn NY
Errol D. Goddard - Somerville NJ
Arminda G. Barbone - Union NJ
Adolf Leshchiner - Fairview NJ
Joseph P. Pavlichko - Helmetta NJ
M. Partain - Bound-Brook NJ
Pak S. Leung - Highland Mills NY

Biomatrix, Inc. - Ridgefield NJ
Union Carbide Chemicals and Plastics Company Inc. - Danbury CT

C08L 100
A61K 709
B32B 902

106162

Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.

47674636, Aug 30, 1988

Apr 15, 1987

7/038836

George L. Brode - Bridgewater NJ
Philip A. Band - Brooklyn NY
Errol D. Goddard - Somerville NJ
Arminda G. Barbone - Union NJ
Adolf Leshchiner - Fairview NJ
Joseph P. Pavlichko - Helmetta NJ
Emmett M. Partain - Bound Brook NJ
Pak S. Leung - Highland Mills NY

Union Carbide Corporation - Danbury CT

C08L 100
A61K 709

106162

Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.

46296239, Dec 16, 1986

Jun 11, 1984

6/619534

Endre A. Balazs - Riverdale NY
Adolf Leshchiner - Brooklyn NY

Biomatrix, Inc. - Ridgefield NJ

A61K 3174
A61K 706
A61K 715

424 78

Disclosed are water based, viscoelastic compositions comprising a mixture of high molecular weights hyaluronic salts and water soluble poly(ethylene oxides). Also disclosed are cosmetic formulations including said compositions.