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Achim Horst Krotz

from Rockville, MD
Age ~63
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Also known as:
Achim H Krotz, Achim J Krotz, Achim M Krotz, Achim H Krot, Rotc K Achim, Noe Castillo, Noe Munoz
Related to:
Steven V Thomas, 31Alex JulioHumberto Julio, 70Judith Anglin, 69Juan NononAmanda Muniz
Connected to:
Anita M Krotz, 75Daniel T Krotz, 43Michael P Krotz, 66Randolph Krotz, 78Rebecca A Krotz, 29Ruth A Krotz, 71Stephanie V Krotz, 29Dennis A Krotzer, 51Solomon Krotzer, 40Edward Y Kroub, 45

Achim Krotz Phones & Addresses

  • Rockville, MD
  • 10616 Penara St, San Diego, CA 92126 (858) 566-6743
  • 13280 Evening Sky Ct, San Diego, CA 92130 (858) 925-7143
  • 6913 Westleigh Pl, San Diego, CA 92126
  • Irvine, CA
  • Carlsbad, CA
  • Pasadena, CA

Work

Position: Clerical/White Collar

Education

Degree: Graduate or professional degree

Emails

j***[email protected]

Resumes

Resumes

Achim Krotz Photo 1

Achim Krotz

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Location:
San Diego, CA
Industry:
Biotechnology
Achim Krotz Photo 2

Achim Krotz

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Location:
San Diego, CA
Industry:
Biotechnology
Work:
Sr. Manager at Pacira Pharmaceuticals 2007 - 2009
Pacira Pharmaceuticals

Publications

Us Patents

Process For The Synthesis Of Oligomeric Compounds

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US Patent:
6465628, Oct 15, 2002
Filed:
Apr 9, 1999
Appl. No.:
09/288679
Inventors:
Vasulinga T. Ravikumar - Carlsbad CA
Muthiah Manoharan - Carlsbad CA
Daniel C. Capaldi - San Diego CA
Achim Krotz - San Diego CA
Douglas L. Cole - San Diego CA
Andrei Guzaev - Carlsbad CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C02H 2100
US Classification:
536 231, 536 243, 536 245, 536 2531, 536 2533, 536 2534
Abstract:
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.

Purification Of Oligonucleotides

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US Patent:
6586586, Jul 1, 2003
Filed:
Jan 31, 2000
Appl. No.:
09/495398
Inventors:
Achim H. Krotz - San Diego CA
Vasulinga T. Ravikumar - Carlsbad CA
Assignee:
Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2100
US Classification:
536 254
Abstract:
Methods and compounds useful for the purification of oligonucleotides and their analogs are provided wherein the oligonucleotides are contaminated with at least one oligonucleotide having at least one abasic site by the formation of imines at the aldehyde moiety of the abasic site and subsequent separation based on extractions, precipitations or chromatography.

Methods For Removing Dimethoxytrityl Groups From Oligonucleotides

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US Patent:
6794502, Sep 21, 2004
Filed:
Mar 22, 2002
Appl. No.:
10/103906
Inventors:
Achim H. Krotz - San Diego CA
Bethany M. McElroy - San Marcos CA
Anthony N. Scozzari - Vista CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2100
US Classification:
536 2531, 536 271, 536 2713
Abstract:
The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5â-OH protecting group at the 5â-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5â-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.

Synthesis Of Oligonucleotides On Solid Support

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US Patent:
6822088, Nov 23, 2004
Filed:
Jul 16, 2002
Appl. No.:
10/196090
Inventors:
Max Moore - Encinitas CA
Achim H. Krotz - San Diego CA
Mark Andrade - Vista CA
Anthony N. Scozzari - Vista CA
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 2100
US Classification:
536 253, 536 2531, 536 2533, 536 2534
Abstract:
The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.

Process For The Synthesis Of Oligomeric Compounds

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US Patent:
6858715, Feb 22, 2005
Filed:
Aug 30, 2002
Appl. No.:
10/232881
Inventors:
Vasulinga T. Ravikumar - Carlsbad CA, US
Muthiah Manoharan - Carlsbad CA, US
Daniel C. Capaldi - San Diego CA, US
Achim Krotz - San Diego CA, US
Douglas L. Cole - San Diego CA, US
Andrei Guzaev - Carlsbad CA, US
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H021/00
US Classification:
536 231, 536 243, 536 245, 536 2531, 536 2534
Abstract:
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.

Process For The Synthesis Of Oligomeric Compounds

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US Patent:
7041816, May 9, 2006
Filed:
Jan 20, 2004
Appl. No.:
10/760940
Inventors:
Vasulinga T. Ravikumar - Carlsbad CA, US
Muthiah Manoharan - Carlsbad CA, US
Daniel C. Capaldi - San Diego CA, US
Achim Krotz - San Diego CA, US
Douglas L. Cole - San Diego CA, US
Andrei Guzaev - Carlsbad CA, US
Assignee:
ISIS Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 21/00
US Classification:
536 2531, 536 231, 536 243, 536 245, 536 2533, 536 2534
Abstract:
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.

Chloral-Free Dca In Oligonucleotide Synthesis

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US Patent:
7169916, Jan 30, 2007
Filed:
Mar 31, 2003
Appl. No.:
10/403692
Inventors:
Achim Krotz - San Diego CA, US
Daniel Capaldi - Encinitas CA, US
Hans Gaus - Vista CA, US
Brett Turney - San Diego CA, US
Assignee:
Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 21/00
US Classification:
536 253, 536 2533, 536 2534
Abstract:
A process of manufacturing oligonucleotides includes a 5′-deblocking step in which the 5-blocking group is removed with dichloroacetic acid that is essentially free of chloral. The process is useful for making oligonucleotides that are substantially free of chloral adducts.

Process For The Synthesis Of Oligomeric Compounds

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US Patent:
7186822, Mar 6, 2007
Filed:
Dec 28, 2004
Appl. No.:
11/025791
Inventors:
Vasulinga Ravikumar - Carlsbad CA, US
Muthiah Manoharan - Weston MA, US
Daniel C. Capaldi - Carlsbad CA, US
Achim Krotz - San Diego CA, US
Douglas L. Cole - Half Moon Bay CA, US
Andrei P. Guzaev - Vista CA, US
Assignee:
Isis Pharmaceuticals, Inc. - Carlsbad CA
International Classification:
C07H 21/00
US Classification:
536 2531, 536 2533, 536 2534, 536 231, 536 243, 536 245
Abstract:
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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Achim Horst Krotz from Rockville, MD, age ~63 Get Report