Inventors:
Stephen Baker - Mountain View CA, US
Tsutomu Akama - Sunnyvale CA, US
Michael Alley - Santa Clara CA, US
Steven Benkovic - State College PA, US
Michael DiPierro - Wadsworth IL, US
Vincent Hernandez - Watsonville CA, US
Karin Hold - Belmont CA, US
Isaac Kennedy - Bolingbrook IL, US
Igor Likhotvorik - Naperville IL, US
Weimin Mao - Sunnyvale CA, US
Kirk Maples - San Jose CA, US
Jacob Plattner - Berkeley CA, US
Fernando Rock - Los Altos CA, US
Virginia Sanders - San Francisco CA, US
Aaron Stemphoski - Florence SC, US
George Yiannikouros - Florence SC, US
Siead Zegar - Orland Park IL, US
Yong-Kang Zhang - San Jose CA, US
Huchen Zhou - Shanghai, CN
Assignee:
Anacor Pharmaceuticals - Palo Alto CA
International Classification:
A61K 31/69
C07F 5/02
US Classification:
514064000, 558286000, 562007000
Abstract:
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.