Ko Lin Phones & Addresses
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253 Lincoln St, Lexington, MA 02421 (781) 863-9555
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Cambridge, MA
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Saint Louis, MO
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Ann Arbor, MI
Business Records
Name / Title
Company / Classification
Phones & Addresses
Principal
J & G PROFESSIONAL SERVICE INC
Services-Misc
Services-Misc
25 Tallard Rd, Westford, MA 01886
Publications
Us Patents
Adenosine Receptor Antagonists And Methods Of Making And Using The Same
View pageUS Patent:
7579354, Aug 25, 2009
Filed:
Jul 10, 2006
Appl. No.:
11/484805
Inventors:
William F. Kiesman - Wayland MA, US
Carol L. Ensinger - Chelmsford MA, US
Russell C. Petter - Stow MA, US
James E. Dowling - Scituate MA, US
Gnanasambandam Kumaravel - Westford MA, US
He Xi Chang - Belmont MA, US
Ko Chung Lin - Lexington MA, US
Carol L. Ensinger - Chelmsford MA, US
Russell C. Petter - Stow MA, US
James E. Dowling - Scituate MA, US
Gnanasambandam Kumaravel - Westford MA, US
He Xi Chang - Belmont MA, US
Ko Chung Lin - Lexington MA, US
International Classification:
A61P 9/08
A61P 9/10
A61P 13/12
A61P 9/04
A61K 31/522
C07D 519/00
C07D 473/06
A61P 11/06
A61P 3/10
A61P 9/10
A61P 13/12
A61P 9/04
A61K 31/522
C07D 519/00
C07D 473/06
A61P 11/06
A61P 3/10
US Classification:
51426334, 514 81, 51426322, 51426324, 51426335, 51426336
Abstract:
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine Areceptor. Adenosine Aantagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:.
Adenosine Receptor Antagonists And Methods Of Making And Using The Same
View pageUS Patent:
20040067966, Apr 8, 2004
Filed:
Aug 21, 2003
Appl. No.:
10/646454
Inventors:
William Kiesman - Wayland MA, US
Carol Ensinger - Chelmsford MA, US
Russell Petter - Stow MA, US
James Dowling - Scituate MA, US
Gnanasambandam Kumaravel - Westford MA, US
He Chang - Belmont MA, US
Ko Lin - Lexington MA, US
Carol Ensinger - Chelmsford MA, US
Russell Petter - Stow MA, US
James Dowling - Scituate MA, US
Gnanasambandam Kumaravel - Westford MA, US
He Chang - Belmont MA, US
Ko Lin - Lexington MA, US
Assignee:
Biogen, Inc.
International Classification:
A61K031/522
C07D473/02
C07D473/02
US Classification:
514/263200, 514/263240, 514/263340, 544/268000, 544/267000
Abstract:
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine Areceptor. Adenosine Aantagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula 1:
Adenosine Receptor Antagonists And Methods Of Making And Using The Same
View pageUS Patent:
20070015732, Jan 18, 2007
Filed:
Jul 13, 2006
Appl. No.:
11/487764
Inventors:
William Kiesman - Wayland MA, US
Carol Ensinger - Chelmsford MA, US
Russell Petter - Stow MA, US
James Dowling - Scituate MA, US
Gnanasambandam Kumaravel - Westford MA, US
He Chang - Belmont MA, US
Ko Lin - Lexington MA, US
Carol Ensinger - Chelmsford MA, US
Russell Petter - Stow MA, US
James Dowling - Scituate MA, US
Gnanasambandam Kumaravel - Westford MA, US
He Chang - Belmont MA, US
Ko Lin - Lexington MA, US
International Classification:
A61K 31/675
A61K 31/522
C07F 9/6512
C07D 473/02
A61K 31/522
C07F 9/6512
C07D 473/02
US Classification:
514081000, 544244000, 544267000, 544268000, 544269000, 514263200, 514263300, 514263230, 514263240
Abstract:
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine Areceptor. Adenosine Aantagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I:
Adenosine Receptor Antagonists And Methods Of Making And Using The Same
View pageUS Patent:
6649600, Nov 18, 2003
Filed:
Nov 13, 2000
Appl. No.:
09/711543
Inventors:
William F. Kiesman - Wayland MA
Carol L. Ensinger - Chelmsford MA
Russell C. Petter - Stow MA
James E. Dowling - Scituate MA
Gnanasambandam Kumaravel - Westford MA
He Xi Chang - Belmont MA
Ko Chung Lin - Lexington MA
Carol L. Ensinger - Chelmsford MA
Russell C. Petter - Stow MA
James E. Dowling - Scituate MA
Gnanasambandam Kumaravel - Westford MA
He Xi Chang - Belmont MA
Ko Chung Lin - Lexington MA
Assignee:
Biogen, Inc. - Cambridge MA
International Classification:
C07D51900
US Classification:
514 81, 51426322, 51426324, 51426334, 51426335, 51426336, 544244, 544267, 544268, 544270, 544271, 544272, 544273
Abstract:
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A receptor. Adenosine A antagonists can be usefull in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I: wherein: R is an optionally substituted bicyclic, tricylic, or pentacyclic group selected from: âand wherein R , R , R , X , X , and Z are as described in the specification.